Relative frequency, Possible Risk Factors, Viral Codetection Rates, and Seasonality of Respiratory Syncytial Virus Among Children With Lower Respiratory Tract Infection in Northeastern Brazil.
Relative frequency, Possible Risk Factors, Viral Codetection Rates, and Seasonality of Respiratory Syncytial Virus Among Children With Lower Respiratory Tract Infection in Northeastern Brazil.
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DOI：
10.1097/md.0000000000003090
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发表时间：
2016-04
期刊：
影响因子：
1.6
通讯作者：
Peixoto RB
中科院分区：
文献类型：
--
作者：
Gurgel RQ;Bezerra PGM;Duarte MDCMB;Moura AÁ;Souza EL;Silva LSDS;Suzuki CE;Peixoto RB
很少有研究，每个限于一个主要城市，调查了不同的病毒在巴西东北部儿童下呼吸道感染（LRTI）的流行和季节性模式。本研究的目的是确定呼吸道合胞病毒（RSV）和其他7种病毒在该地区4个首都的儿童LRTI中的频率，并调查其与几个危险因素的关系，包括气象数据。从2012年4月至2013年3月，在阿拉卡茹、萨尔瓦多、累西腓和马塞约的一个参与中心，收集了507名年龄在24个月以下并因LRTI住院的儿童的鼻咽抽吸物样本，并通过逆转录聚合酶链反应分析了以下病毒，然后在低密度微阵列上进行杂交：RSV、流感、副流感、腺病毒、鼻病毒、偏肺病毒、博卡病毒和冠状病毒。阳性率为66.5%，以呼吸道合胞病毒（RSV）最常见（40.2%）。除鼻病毒（17%）外，其他病毒的检出率均低于6%。在13.8%的样本中检测到病毒合并感染。RSV感染的可能相关危险因素是入组时年龄低、参加日托、胎龄低和父亲教育水平低。病毒感染的相对频率分别与温度升高和湿度降低有关，但结果也表明两者均与RSV频率增加有关。其中一些调查结果与巴西其他地区报告的调查结果不同，可用于指导解决LRTI的政策。
Few studies, each limited to a single major city, have investigated the prevalence and seasonal patterns of different viruses among children with low respiratory tract infections (LRTI) in Northeastern Brazil. The aim of this study was to determine the frequency of respiratory syncytial virus (RSV) and of 7 other viruses in children for LRTI in 4 capitals from this region, and investigate their association with several risk factors, including meteorological data. From April 2012 to March 2013, 507 children, aged up to 24 months and hospitalized with LRTI in one of the participating centers at Aracajú, Salvador, Recife, and Maceió, had a sample of nasopharyngeal aspirate collected and analyzed for the following viruses by reverse-transcription polymerase chain reaction followed by hybridization on low-density microarrays: RSV, influenza, parainfluenza, adenovirus, rhinovirus, metapneumovirus, bocavirus, and coronavirus. The result was positive in 66.5% of cases, RSV was the most common virus (40.2%). Except for rhinovirus (17%), all other virus had frequency rates lower than 6%. Viral coinfections were detected in 13.8% of samples. Possible related risk factors for RSV infection were low age upon entry, attendance of daycare, low gestational age, and low educational level of the father. The relative frequency of viral infections was associated with increasing temperature and decreasing humidity separately, but the results also suggested both associated with increased frequency of RSV. Some of these findings differ from those reported for other regions in Brazil and may be used to guide policies that address LRTI.