RAPID COMMUNICATION: ABNORMAL SUPPRESSION OF PLASMA CORTISOL DURING THE INTRAVENOUS INFUSION OF DEXAMETHASONE TO ALCOHOLIC PATIENTS
RAPID COMMUNICATION: ABNORMAL SUPPRESSION OF PLASMA CORTISOL DURING THE INTRAVENOUS INFUSION OF DEXAMETHASONE TO ALCOHOLIC PATIENTS
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快速沟通：酒精患者静脉输注地塞米松期间血浆皮质醇的异常抑制
DOI：
10.1111/j.1365-2265.1981.tb02755.x
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发表时间：
1981
影响因子：
3.2
通讯作者：
V. James
中科院分区：
文献类型：
--
作者：
R. Fink;F. Short;D. Marjot;V. James
。在某些情况下，酒精患者口服地塞米松未能引起血浆皮质醇水平的正常下降。虽然酗酒者经常表现出肠道吸收不良的迹象，但以前没有考虑到地塞米松未完全吸收的可能性。为了消除任何吸收不良的问题，10例男性酒精患者静脉注射地塞米松（1mg/h）。在输注2小时的过程中，每隔半小时抽取血液样本中的血浆皮质醇水平与10名同样输注的正常受试者的血浆皮质醇水平进行比较。四名酗酒者血浆皮质醇水平未显示正常抑制，从而证实在一些酗酒者中存在与库欣病相似的垂体-肾上腺功能紊乱。在这4个病例中，只有1例抑制失败通常与库欣病的临床症状有关。
. In some cases the oral administration of dexamethasone to alcoholic patients has failed to cause a normal depression of plasma cortisol levels. Although alcoholics often show signs of intestinal malabsorption, the possibility that the dexamethasone was not fully absorbed has not previously been considered. To eliminate any question of malabsorption, ten male alcoholic patients were infused intravenously with dexamethasone (1mg/h). The plasma cortisol levels in blood samples withdrawn at half‐hourly intervals during a 2‐h infusion were compared with the values found in ten normal subjects similarly infused. Four of the alcoholics failed to show normal suppression of plasma cortisol levels, thus confirming that in some alcoholics there is a disturbance of pituitary‐adrenal function similar to that found in Cushing's disease. In only one of the four cases was failure to suppress normally associated with the presence of clinical signs of Cushing's disease.