Hypertension, hyperlipidemia and microalbuminuria.
Hypertension, hyperlipidemia and microalbuminuria.
复制标题
高血压、高脂血症和微量白蛋白尿。
DOI：
10.1159/000059818
复制
发表时间：
1997
影响因子：
--
通讯作者：
Bigazzi,R
中科院分区：
文献类型：
--
作者：
Campese,VM;Bianchi,S;Bigazzi,R
高脂血症和蛋白尿经常联系在一起。包括这两个因素的最显著的临床状况是肾病综合征，其中蛋白尿水平升高、血清总胆固醇水平升高和高密度脂蛋白（HDL）胆固醇降低是肾病的三个主要症状。正常蛋白尿的减少伴随着异常脂质谱的正常化。高脂血症和尿白蛋白排泄增加也常与原发性高血压患者相关。这就提出了关于这两个参数之间的因果关系的问题。此外，还没有对这种关联提供机械的解释。来自肾病综合征患者的证据表明，高脂血症可能是尿原所致。然而，最近一些作者提出高脂血症可能在肾脏疾病的进展中起积极作用。这就提出了高脂血症可能是原发性高血压患者肾损害和伴随的微量白蛋白尿或蛋白尿的原因。本文旨在探讨原发性高血压患者微量白蛋白尿与高脂血症之间关系的证据和意义。
Hyperlipidemia and proteinuria are frequently linked. The most notable clinical condition including these two factors is the nephrotic syndrome in which higher levels of proteinuria, elevated serum total cholesterol levels and reduced high-density lipoprotein (HDL) cholesterol represent three of the major signs of the disease. The reduction of normal proteinuria is followed by a normalization of the abnormal lipid profile. Hyperlipidemia and increased urinary albumin excretion are also frequently linked in patients with essential hypertension. This has raised questions regarding the cause-effect relationship between these two parameters. Moreover, no mechanistic explanation has been provided for this association. The evidence from patients with nephrotic syndrome would suggest that hyperlipidemia may be a consequence of pro-teinuria. More recently, however, some authors have suggested that hyperlipide-mia may play an active role in the progression of renal diseases. This raises the possibility that hyperlipidemia may be responsible for the renal damage and the attendant microalbuminuria or proteinuria in patients with essential hypertension. The purpose of this review is to discuss the evidence and the significance of the relationship between microalbuminuria and hyperlipidemia in patients with essential hypertension.