Cryoglobulinemia and glomerular rhomboid inclusions in a child with acute kidney injury.

Cryoglobulinemia and glomerular rhomboid inclusions in a child with acute kidney injury.
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急性肾损伤儿童的冷球蛋白血症和肾小球菱形包涵体。

DOI:
10.1053/j.ajkd.2009.01.015
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发表时间:
2009
期刊:
American journal of kidney diseases : the official journal of the National Kidney Foundation
影响因子:
--
通讯作者:
Primack,William
Primack,William
中科院分区:
--
文献类型:
--
作者:
Nester,CarlaM;Benner,EricJ;Latour,Mathieu;Nickeleit,Volker;Hamrick,Harvey;Primack,William

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Cryoglobulinemia is rarely reported in children, and kidney failure secondary to cryoglobulinemia is even more uncommon. We report the case of a 7-year-old boy with cryoglobulins and a systemic illness, including persistent fever, arthralgias, rash, hypocomplementemia, and acute kidney injury associated with nephritic urine sediment. An extensive workup showed no infectious, neoplastic, or rheumatological cause of his kidney injury. The kidney biopsy specimen showed membranoproliferative glomerulonephritis type 1 with electron microscopic evidence of rhomboid crystalloid inclusions. These inclusions have rarely been reported in adult patients with cryoglobulinemia. The patient underwent spontaneous remission, including full recovery of kidney function, and required no immune suppression. The patient's course is consistent with cryoglobulinemia-associated kidney injury, which supports the inclusion of essential cryoglobulinemia in the differential diagnosis of pediatric patients with hypocomplementemic glomerulonephritis.
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