Prospective Study of Restless Legs Syndrome and Risk of Depression in Women
Prospective Study of Restless Legs Syndrome and Risk of Depression in Women
复制标题
DOI：
10.1093/aje/kws016
复制
发表时间：
2012-08-15
影响因子：
5
通讯作者：
Gao, Xiang
中科院分区：
文献类型：
--
作者：
Li, Yanping;Mirzaei, Fariba;Gao, Xiang
大多数关于不宁腿综合征（RLS）和抑郁症之间关系的研究都涉及横截面数据。本研究的目的是前瞻性地评估护士健康研究参与者之间的这个问题。共有56,399名女性（平均年龄68岁）在基线（2002年）没有抑郁症状，直到2008年被随访。医生诊断的RLS是自我报告的。在300，155人年的随访中，作者确定了1，268例临床抑郁症事件（定期使用抗抑郁药物和医生诊断的抑郁症）。基线时有RLS的女性比无RLS的女性更容易发生临床抑郁症（多变量校正的相对风险（RR）1.5，95置信区间（CI）：1.1，2.1; P 0.02）。基线时RLS的存在也与10项流行病学研究中心抑郁量表（CESD-10）和15项老年抑郁量表（GDS-15）的较高评分相关。RLS女性和无RLS女性之间CESD-10评分和GDS-15评分的多变量校正平均差异分别为1.00（标准误，0.12）和0.47（标准误，0.07）（P 0.0001）。总之，经医生诊断为RLS的女性患临床抑郁症和临床相关抑郁症状的风险增加。进一步的前瞻性研究，使用完善的方法来确定RLS和抑郁症是必要的。
Most research on the association between restless legs syndrome (RLS) and depression has involved cross-sectional data. The objective of the present study was to evaluate this issue prospectively among Nurses Health Study participants. A total of 56,399 women (mean age 68 years) who were free of depression symptoms at baseline (2002) were followed until 2008. Physician-diagnosed RLS was self-reported. During 300,155 person-years of follow-up, the authors identified 1,268 incident cases of clinical depression (regular use of antidepressant medication and physician-diagnosed depression). Women with RLS at baseline were more likely to develop clinical depression (multivariate-adjusted relative risk (RR) 1.5, 95 confidence interval (CI): 1.1, 2.1; P 0.02) than those without RLS. The presence of RLS at baseline was also associated with higher scores on the 10-item Center for Epidemiologic Studies Depression Scale (CESD-10) and the 15-item Geriatric Depression Scale (GDS-15) thereafter. Multivariable-adjusted mean differences were 1.00 (standard error, 0.12) for CESD-10 score and 0.47 (standard error, 0.07) for GDS-15 score between women with RLS and those without RLS (P 0.0001). In conclusion, women with physician-diagnosed RLS had an increased risk of developing clinical depression and clinically relevant depression symptoms. Further prospective studies using refined approaches to ascertainment of RLS and depression are warranted.