Prognostic Significance of Serum Alkaline Phosphatase Level in Osteosarcoma: A Meta-Analysis of Published Data.
Prognostic Significance of Serum Alkaline Phosphatase Level in Osteosarcoma: A Meta-Analysis of Published Data.
复制标题
骨肉瘤血清碱性磷酸酶水平的预后意义：已发表数据的荟萃分析。
DOI：
10.1155/2015/160835
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发表时间：
2015
影响因子：
--
通讯作者：
Ye ZM
中科院分区：
文献类型：
--
作者：
Ren HY;Sun LL;Li HY;Ye ZM
背景血清碱性磷酸酶（SALP）通常在骨肉瘤患者中升高。许多研究调查了SALP水平在骨肉瘤患者中的预后作用，但结果不一致。法在PubMed、Embase和Web of Science数据库中对相关原始文章进行系统计算机检索。计算合并危险比（HR）和相对危险度（RR）及相应的置信区间（CI），以评估SALP水平的预后价值。结果最后，纳入了21项研究，包括3228例患者。总体而言，SALP的合并HR表明，升高的水平对骨肉瘤患者的总生存期（OS）（HR = 1.82; 95% CI：1.61-2.06; p < 0.001）和无事件生存期（EFS）（HR = 1.97; 95% CI：1.61-2.42; p < 0.001）有不利影响。SALP的合并RR表明，水平升高与诊断时存在转移相关（RR = 5.55; 95%CI：1.61-9.49; p = 0.006）。在按年龄范围、癌症分期、样本量和地理区域等变量分层后，没有获得显著差异的结果。结论这项荟萃分析表明，高SALP水平与OS或EFS率低和诊断时存在转移显著相关。SALP水平是判断骨肉瘤预后的一个简便有效的生物标志物。
Background. Serum alkaline phosphatase (SALP) is commonly elevated in osteosarcoma patients. A number of studies have investigated the prognostic role of SALP level in patients with osteosarcoma but yielded inconsistent results. Method. Systematic computerized searches were performed in PubMed, Embase, and Web of Science databases for relevant original articles. The pooled hazard ratios (HRs) and relative risks (RRs) with corresponding confidence intervals (CIs) were calculated to assess the prognostic value of SALP level. Results. Finally, 21 studies comprising 3228 patients were included. Overall, the pooled HRs of SALP suggested that elevated level had an unfavorable impact on osteosarcoma patients' overall survival (OS) (HR = 1.82; 95% CI: 1.61–2.06; p < 0.001) and event-free survival (EFS) (HR = 1.97; 95% CI: 1.61–2.42; p < 0.001). Combined RRs of SALP indicated that elevated level was associated with presence of metastasis at diagnosis (RR = 5.55; 95% CI: 1.61–9.49; p = 0.006). No significantly different results were obtained after stratified by variables of age range, cancer stage, sample size, and geographic region. Conclusion. This meta-analysis demonstrated that high SALP level is significantly associated with poor OS or EFS rate and presence of metastasis at diagnosis. SALP level is a convenient and effective biomarker of prognosis for osteosarcoma.