Cannabinoid concentrations in plasma after passive inhalation of marijuana smoke.
Cannabinoid concentrations in plasma after passive inhalation of marijuana smoke.
复制标题
被动吸入大麻烟雾后血浆中大麻素的浓度。
DOI：
10.1093/jat/7.4.172
复制
发表时间：
1983
影响因子：
2.5
通讯作者：
Foltz,RL
中科院分区：
文献类型：
--
作者：
Mason,AP;Perez-Reyes,M;McBay,AJ;Foltz,RL
Δ-9-四氢大麻酚（THC）及其代谢物9-羧基-THC在受试者的血浆中在一小时被动暴露于来自总共含有104.8 mg THC的四支大麻香烟的烟雾期间被检测到。通过RIA测定THC的血浆浓度，并在暴露20分钟后达到2.2ng/mL的表观稳态浓度。通过GC/MS分析确认THC的存在。两种分析的结果显示出良好的相关性（r = 0.990），尽管GC/MS测定的浓度高于RIA测定的浓度。9.羧基-THC的浓度也通过GC/MS测定，并且始终保持低于GC/MS测定的THC浓度。通过输注THC，被动暴露期间吸入和吸收的剂量估计为3.2µg/min。
Δ-9-tetrahydrocannabinol (THC) and its metabolite, 9-carboxy-THC, were detected in the plasma of a subject during a one-hour passive exposure to the smoke from four marijuana cigarettes containing a total of 104.8 mg of THC. plasma concentrations of THC were determined by RIA and reached an apparent steady-state concentration of 2.2 ng/mL after 20 minutes of exposure. The presence of THC was confirmed by GC/MS analysis. Results from the two analyses exhibited excellent correlation (r = 0.990), although the concentrations determined by GC/MS were higher than those determined by RIA. Concentrations of 9.carboxy-THC were also determined by GC/MS, and remained consistently below the GC/MS determined concentrations of THC. By administering an infusion of THC, the dose that was inhaled and absorbed during the passive exposure was estimated to be 3.2µg/min.