Predictive biomarkers of ossification progression and bone metabolism dynamics in patients with cervical ossification of the posterior longitudinal ligament
Predictive biomarkers of ossification progression and bone metabolism dynamics in patients with cervical ossification of the posterior longitudinal ligament
复制标题
颈椎后纵韧带骨化患者骨化进展和骨代谢动力学的预测生物标志物
DOI：
10.1007/s00586-023-07565-z
复制
发表时间：
2023
影响因子：
2.8
通讯作者：
Kawashima Hiroyuki
中科院分区：
文献类型：
--
作者：
Katsumi Keiichi;Watanabe Kei;Yamazaki Akiyoshi;Hirano Toru;Ohashi Masayuki;Mizouchi Tatsuki;Sato Masayuki;Sekimoto Hiroyuki;Izumi Tomohiro;Shibuya Yohei;Kawashima Hiroyuki
目的本研究旨在通过检测后纵韧带骨化（OPLL）患者的骨化体积和骨代谢动力学来建立预测骨化进展的生物标志物。方法我们使用基于计算机断层扫描的三维（3D）图像分析来评估107例OPLL患者的OPLL进展，并检测骨代谢动力学（男性，72;女性，35;平均年龄，63.6岁）。在随访期间计算两次OPLL体积，并通过骨化年增长率评估OPLL进展。通过常规血液检查和各种血清生物标志物（包括25-羟基维生素D、完整甲状旁腺激素、成纤维细胞生长因子23、1型完整N-末端前肽、抗酒石酸酸性磷酸酶亚型5 b、硬化蛋白和Dickkopf-1）和骨密度（BMD）分析评估骨代谢动力学。患者被分为进展（P）或非进展（NP）组根据以前的3D图像分析的年增长率，这些组之间的相关因素进行了compared.ResultsThe P和NP组包括29例患者（23名男性和6名女性）和78例患者（49名男性和29名女性），分别。单因素分析显示年龄、体重指数、血磷、血清硬化素和骨密度有显著差异。在多因素分析中，年龄，血清磷，血清sclerostin被确定为独立因素与OPLL progress.ConclusionYounger年龄，低磷血症，高血清sclerostin是OPLL进展的危险因素。血清磷和硬化素可作为预测骨化进展的重要生物标志物。
PurposeThis study aimed to establish biomarkers to predict the progression of ossification by examining ossification volume and bone metabolism dynamics in patients with ossification of the posterior longitudinal ligament (OPLL).MethodsWe assessed OPLL progression using computed tomography-based three-dimensional (3D) image analysis and examined bone metabolism dynamics in 107 patients with OPLL (men, 72; women, 35; mean age, 63.6 years). The volume of OPLL was calculated twice during the follow-up period, and OPLL progression was evaluated by the annual rate of ossification increase. Bone metabolism dynamics were assessed by routine blood tests and analysis of various serum biomarkers (including 25-hydroxyvitamin D, intact parathyroid hormone, fibroblast growth factor 23, intact N-terminal propeptide of type 1, tartrate-resistant acid phosphatase isoform 5b, sclerostin, and Dickkopf-1) and bone mineral density (BMD). Patients were classified into the progression (P) or non-progression (NP) group according to the annual rate of increase in previous 3D image analyses, and associated factors between these groups were compared.ResultsThe P and NP groups consisted of 29 patients (23 men and 6 women) and 78 patients (49 men and 29 women), respectively. Univariate analysis revealed significant differences in terms of age, body mass index, serum phosphorus, serum sclerostin, and BMD. In multivariate analysis, age, serum phosphorus, and serum sclerostin were identified as independent factors associated with OPLL progression.ConclusionYounger age, hypophosphatemia, and high serum sclerostin are risk factors for OPLL progression. Serum phosphorus and sclerostin could serve as important biomarkers for predicting ossification progression.
登录
查看更多内容
影响因子：
4.1
作者：
Endo, Itsuro;Fukumoto, Seiji;Matsumoto, Toshio
通讯作者：
Matsumoto, Toshio
影响因子：
4.1
作者：
Iwasaki, M;Kawaguchi, Y;Yonenobu, K
通讯作者：
Yonenobu, K
影响因子：
4.5
作者：
Lee, Jong Joo;Shin, Dong Ah;Ha, Yoon
通讯作者：
Ha, Yoon
在糖尿病患者中使用噻唑烷二酮和结直肠癌的风险：全国，基于人群的病例对照研究。
影响因子：
16.2
作者：
Chen SW;Tsan YT;Chen JD;Hsieh HI;Lee CH;Lin HH;Wang JD;Chen PC;Health Data Analysis in Taiwan Research Group
通讯作者：
Health Data Analysis in Taiwan Research Group
影响因子：
3
作者：
Hori, Takeshi;Kawaguchi, Yoshiharu;Kimura, Tomoatsu
通讯作者：
Kimura, Tomoatsu