Fulminant Skin GvHD With a Cytokine Pattern Resemblant of Cytokine Release Syndrome Successfully Treated With Multimodal Immunosuppression Including Tocilizumab
Fulminant Skin GvHD With a Cytokine Pattern Resemblant of Cytokine Release Syndrome Successfully Treated With Multimodal Immunosuppression Including Tocilizumab
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DOI：
10.1002/pbc.25595
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发表时间：
2015-11-01
影响因子：
3.2
通讯作者：
Woelfl, Matthias
中科院分区：
文献类型：
--
作者：
Hellwig, Yuliya;Yoo, Young E.;Woelfl, Matthias
Acute Graft-versus-Host-Disease (GvHD) is a potentially life-threatening complication after allogeneic stem cell transplantation. If not treated early and adequately, the complex immunological mechanisms may lead to a self-perpetuating cycle of alloreactivity, which is then associated with a high mortality. Here we assessed the cytokine profile on a daily basis in a patient with grade 4 skin GvHD, demonstrating a signature resembling cytokine-release-syndrome. After multimodal immunosuppressive intervention, including treatment with the IL6 receptor-blocking antibody tocilizumab, the severe clinical symptoms unexpectedly resolved within 48hr. (C) 2015 Wiley Periodicals, Inc.
