Family and personal medical history and risk of meningioma Clinical article
Family and personal medical history and risk of meningioma Clinical article
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DOI：
10.3171/2011.6.jns11129
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发表时间：
2011-12-01
影响因子：
4.1
通讯作者：
Wrensch, Margaret
中科院分区：
文献类型：
--
作者：
Claus, Elizabeth B.;Calvocoressi, Lisa;Wrensch, Margaret
对象。脑膜瘤是美国最常见的原发性脑肿瘤，目前对脑膜瘤的流行病学知之甚少。作者进行了一项病例对照研究，以检查家庭和个人病史与脑膜瘤风险之间的关系。作者比较了2006年5月1日至2010年2月26日期间康涅狄格州、马萨诸塞州、北卡罗来纳州、旧金山湾区和休斯顿8个县1124例脑膜瘤患者（年龄范围20-79岁）的个人和一级家族史，以及1000名年龄、性别和地理位置频率匹配的对照个体的病史。与对照组相比，患者更有可能报告有脑膜瘤一级家族史（OR 4.4,95% CI 1.6-11.5），并且在年轻病例中存在更强的相关性。与对照组相比，患者报告过敏等免疫状况的可能性较小（OR 0.6, 95% CI 0.5-0.7），但更有可能报告甲状腺癌（OR 4.7, 95% CI 1.02-21.5）或白血病（OR 5.4, 95% CI 1.2-24.1）（大多数在放疗后）。在女性中。与对照组相比，患者更有可能报告激素相关疾病——子宫肌瘤（OR 1.2,95% CI 1.0-1.5）、子宫内膜异位症（OR 1.5, 95% CI 1.5-2.1）和乳腺癌（OR 1.4,95% CI 0.8-2.3）。作者的研究结果表明，遗传、免疫系统和头部附近的辐射对脑膜瘤风险的影响；激素的作用很有趣，但需要进一步研究。(DOI: 10.3171 / 2011.6.jns11129)
Object. Little is known about the epidemiology of meningioma, the most frequently reported primary brain tumor in the US. The authors undertook a case-control study to examine the relationship between family and personal medical history and meningioma risk.Methods. The authors compared the personal and first-degree family histories of 1124 patients with meningioma (age range 20-79 years) in Connecticut, Massachusetts, North Carolina, the San Francisco Bay Area, and 8 Houston counties between May I, 2006, and February 26, 2010, and the histories of 1000 control individuals who were frequency-matched for age, sex, and geography.Results. The patients were more likely than the controls to report a first-degree family history of meningioma (OR 4.4,95% CI 1.6-11.5), and there was an even stronger association in younger cases. The patients were less likely than controls to report immune conditions including allergy (OR 0.6, 95% CI 0.5-0.7) but were more likely to report a history of thyroid cancer (OR 4.7, 95% CI 1.02-21.5) or leukemia (OR 5.4, 95% CI 1.2-24.1) (most after radiotherapy). Among women. patients were more likely than controls to report hormonally related conditions-uterine fibroid tumors (OR 1.2,95% CI 1.0-1.5), endometriosis (OR 1.5, 95% CI 1.5-2.1), and breast cancer (OR 1.4,95% Cl 0.8-2.3).Conclusions. The influence of genetics, the immune system, and radiation near the head on meningioma risk is suggested in the authors' findings; the role of hormones is intriguing but requires further study. (DOI: 10.3171/2011.6.JNS11129)