Genomic diversity among Vibrio cholerae O139 strains isolated in Bangladesh and India between 1992 and 1998.
Genomic diversity among Vibrio cholerae O139 strains isolated in Bangladesh and India between 1992 and 1998.
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1992 年至 1998 年间在孟加拉国和印度分离的霍乱弧菌 O139 菌株的基因组多样性。
DOI：
10.1111/j.1574-6968.2000.tb09027.x
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发表时间：
2000
影响因子：
2.1
通讯作者：
Nair,GB
中科院分区：
文献类型：
--
作者：
Faruque,SM;Saha,MN;Asadulghani;Bag,PK;Bhadra,RK;Bhattacharya,SK;Sack,RB;Takeda,Y;Nair,GB
为了评估霍乱弧菌O 139菌株的基因组多样性程度，研究了两个遗传位点rrnandctx的限制性片段长度多态性。对1992年至1998年期间从孟加拉国和印度不同地区分离的144株菌株的分析表明，至少存在6种不同的核糖体型（B-I至B-VI），其中3种是新的核糖体型，其中一种是非产酶O 139菌株。核糖体型B-I至B-V的菌株共有11种不同的CTX基因型（A至K）。菌株的耐药模式独立于其核糖体型和CTX基因型而变化。研究结果表明，V. choleraeO 139正在经历快速的遗传变化，导致新变体的产生，抗菌药物耐药模式的时间变化可能有助于选择不同的变体。
In order to assess the extent of genomic diversity amongVibrio choleraeO139 strains, restriction fragment length polymorphisms in two genetic loci,rrnandctx, were studied. Analysis of 144 strains isolated from different regions of Bangladesh and India between 1992 and 1998 revealed the presence of at least six distinct ribotypes (B-I through B-VI) of which three were new ribotypes, and one of these was represented by a nontoxigenic O139 strain. Strains of ribotypes B-I through B-V shared 11 different CTX genotypes (A through K). Antimicrobial resistance patterns of the strains varied independently of their ribotypes and CTX genotypes. Results of this study suggest thatV. choleraeO139 is undergoing rapid genetic changes leading to the origination of new variants, and temporal changes in antimicrobial resistance patterns may be contributing to the selection of different variants.