INTERACTION OF CORTICOTROPIN-RELEASING FACTOR AND ARGININE VASOPRESSIN ON ADRENOCORTICOTROPIN SECRETION INVIVO
INTERACTION OF CORTICOTROPIN-RELEASING FACTOR AND ARGININE VASOPRESSIN ON ADRENOCORTICOTROPIN SECRETION INVIVO
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DOI：
10.1210/endo-113-3-939
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发表时间：
1983-01-01
期刊：
影响因子：
4.8
通讯作者：
VALE, W
中科院分区：
文献类型：
--
作者：
RIVIER, C;VALE, W
合成羊促肾上腺皮质激素释放因子（CRF）和精氨酸加压素的动物，其内源性CRF释放被阻断氯丙嗪-吗啡-戊巴比妥，AVP之间可能的相互作用引起了显着降低的最大ACTH反应比CRF，而同时注射两种肽导致CRF诱导的ACTH分泌显着增强。在自由活动的大鼠中，AVP在升高血浆ACTH水平方面比CRF更有效（等摩尔基础上）。由于免疫中和的内源性CRF的管理抗CRF血清显着减少ACTH的释放，由于注射AVP在这些动物中，显然至少有一部分的AVP诱导的ACTH分泌在非麻醉大鼠中观察到的内源性CRF的增强外源性AVP。这些数据支持以前的报告，在体外CRF和加压素之间的协同作用，并强调这2肽在体内ACTH释放的相互作用所发挥的复杂作用。
A possible interaction between synthetic ovine corticotropin-releasing factor (CRF) and arginine vasopressin animals whose endogenous CRF release was blocked by chlorpromazine-morphine-nembutal, AVP elicited a significantly lower maximum ACTH response than did CRF, while the concomitant injection of both peptides resulted in a marked potentiation of CRF-induced ACTH secretion. In freely moving rats, AVP was more potent than CRF (on an equimolar basis) in elevating plasma ACTH levels. Since immunoneutralization of endogenous CRF by the administration of anti-CRF serum significantly reduced ACTH release due to injected AVP in these animals, apparently at least part of the AVP-induced ACTH secretion observed in nonanesthetized rats may be to a potentiation of endogenous CRF by exogenously administered AVP. These data support previous reports of an in vitro synergism between CRF and vasopressin, and emphasize the complex role played by the interaction of these 2 peptides on ACTH release in vivo.