Mucosal Immunity Modulated by Integrative Meditation in a Dose-Dependent Fashion
Mucosal Immunity Modulated by Integrative Meditation in a Dose-Dependent Fashion
复制标题
DOI：
10.1089/acm.2009.0234
复制
发表时间：
2010-02-01
影响因子：
2.6
通讯作者：
Posner, Michael I.
中科院分区：
文献类型：
--
作者：
Fan, Yaxin;Tang, Yi-Yuan;Posner, Michael I.
目的：先前的研究表明，与给予相同放松训练量的对照组相比，在急性应激后立即进行额外的训练，增加了接受5天身心综合训练（IBMT）的一组唾液分泌型免疫球蛋白A（sIgA）的释放。然而，5天的训练并没有影响sIgA的基础分泌。目前的研究旨在扩大这一发现，并确定是否增加IBMT的量将增加基础sIgA水平，这表明粘膜免疫functions.Design的进一步改善：三十五（35）中国本科生被随机分配到一个实验组接受4周的IBMT或放松控制。训练前基线和三个阶段（即，结果：训练4周后，实验组基础sIgA水平显著升高，对照组基础sIgA水平无显著变化。在急性应激后立即进行额外的IBMT练习，在第2周和第4周，IBMT训练组与对照组相比产生了显著更高的sIgA释放。结论：IBMT可引起基础免疫系统的改变，且随着训练量的增加，急性效应增强。
Objective: Prior research had shown that an additional training session immediately after acute stress increased release of salivary secretory immunoglobin A (sIgA) in a group trained with 5-day Integrative Body-Mind Training (IBMT) in comparison to a control group given the same amount of relaxation training. However, 5 days of training did not influence the basal secretion of sIgA. The current study seeks to extend this finding and determine whether increasing amounts of IBMT will increase the basal sIgA level, suggesting further improvements in mucosal immune function.Design: Thirty-five (35) Chinese undergraduates were randomly assigned either to an experimental group receiving 4 weeks of IBMT or a relaxation control. Salivary sIgA levels at baseline before training and three stages (i.e., rest, stress, and additional 20-minute practice) after 2 and 4 weeks training were assessed.Results: The basal sIgA levels increased significantly in the experimental subjects but not in controls after 4 weeks of training. An additional IBMT practice session immediately after acute stress produced significantly higher sIgA release for the IBMT-trained group in comparison with controls at week 2 and 4. This effect was larger at week 4 than week 2.Conclusions: These results indicate that the IBMT produces a change in the basal immune system and larger acute effects as the dose of training increases.