Differential effects of bariatric surgery on plasma levels of ANGPTL3 and ANGPTL4.
Differential effects of bariatric surgery on plasma levels of ANGPTL3 and ANGPTL4.
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减肥手术对 ANGPTL3 和 ANGPTL4 血浆水平的不同影响。
DOI：
10.1016/j.numecd.2022.08.019
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发表时间：
2022-11
影响因子：
3.9
通讯作者：
Camastra, Stefania
中科院分区：
文献类型：
--
作者：
Bini, Simone;D'Erasmo, Laura;Astiarraga, Brenno;Minicocci, Ilenia;Palumbo, Maria;Pecce, Valeria;Polito, Luca;Di Costanzo, Alessia;Haeusler, Rebecca A.;Arca, Marcello;Ferrannini, Ele;Camastra, Stefania
血管生成素样3（ANGPTL 3）和4（ANGPTL 4）是甘油三酯储存和利用的调节剂。减肥手术（BS）导致脂肪组织组成和能量代谢的深刻变化。我们评估了BS对血浆ANGPTL 3和ANGPTL 4水平的影响。27例病态肥胖伴或不伴2型糖尿病（T2 D）的受试者接受了Roux-en-Y胃旁路术（RYGB），18例晚期T2 D患者接受了胆胰分流术（BPD）。在基线和手术后1年测量空腹ANGPTL蛋白水平、胰岛素敏感性（通过正常血糖高胰岛素钳夹评估）、总胆汁酸（TBA）和游离脂肪酸（FFA）。两种外科手术均导致脂肪量减少，血糖控制改善，胰岛素敏感性增加约2倍。ANGPTL 4水平在RYGB（26.6 ± 0.6至24.4 ± 0.3 ng/mL，p = 0.001）和BPD（27.9 ± 1.5至24.0 ± 0.5 ng/mL，p = 0.003）的情况下均显著降低。相比之下，ANGPTL 3浓度在RYGB后没有变化，但在BPD后升高（225 ± 20至300 ± 15 ng/mL，p = 0.003）。通过多元回归分析，BS后ANGPTL 4的变化与血糖变化独立相关（p = 0.0169），而ANGPTL 3的变化与FFA（p = 0.008）和胰岛素敏感性（p = 0.043）的变化相关。循环ANGPTL 4被BS降低，可能是由于脂肪量的损失和胰岛素敏感性的改善。相反，ANGPTL 3水平在BPD后增加，但在RYGB后没有增加，可能是因为BPD的吸收不良效应诱导的代谢变化。
Angiopoietin-like 3 (ANGPTL3) and 4 (ANGPTL4) are regulators of triglyceride storage and utilization. Bariatric surgery (BS) leads to profound changes in adipose tissue composition and energy metabolism. We evaluated the impact of BS on plasma levels of ANGPTL3 and ANGPTL4. Twenty-seven subjects affected by morbid obesity with or without type 2 diabetes (T2D) underwent Roux-en-Y gastric bypass (RYGB) and 18 patients with advanced T2D received Biliopancreatic Diversion (BPD). Fasting ANGPTL proteins levels, insulin sensitivity (evaluated by euglycemic hyperinsulinemic clamp), total bile acids (TBA) and free fatty acids (FFA) were measured at baseline and 1 year after surgery. Both surgical procedures resulted in the loss of fat mass, improved glucose control, and a ~2-fold increase of insulin sensitivity. ANGPTL4 levels decreased significantly with both RYGB (26.6 ± 0.6 to 24.4 ± 0.3 ng/mL, p = 0.001) and BPD (27.9 ± 1.5 to 24.0 ± 0.5 ng/mL, p = 0.003). In contrast, ANGPTL3 concentrations did not change after RYGB but rose following BPD (225 ± 20 to 300 ± 15 ng/mL, p = 0.003). By multiple regression analysis, changes after BS in ANGPTL4 were independently associated with changes in blood glucose, (p = 0.0169) whereas changes in ANGPTL3 were associated with variations in FFA (p = 0.008) and insulin sensitivity (p = 0.043). Circulating ANGPTL4 is reduced by BS, probably due to the loss of fat mass and improved insulin sensitivity. Conversely, ANGPTL3 levels increased after BPD, but not after RYGB, presumably because of the metabolic changes induced by the malabsorptive effect of BPD.
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DOI：
10.1007/s40519-021-01194-5
发表时间：
2022-03
期刊：
Eating and weight disorders : EWD
影响因子：
--
作者：
Camastra S;Palumbo M;Santini F
通讯作者：
Santini F
DOI：
10.1016/j.jcmgh.2021.01.012
发表时间：
2021
影响因子：
7.2
作者：
Cariello M;Piccinin E;Moschetta A
通讯作者：
Moschetta A
影响因子：
5.6
作者：
Perdomo CM;Gómez-Ambrosi J;Becerril S;Valentí V;Moncada R;Fernández-Sáez EM;Méndez-Giménez L;Ezquerro S;Catalán V;Silva C;Escalada J;Frühbeck G;Rodríguez A
通讯作者：
Rodríguez A
影响因子：
4.4
作者：
Di Costanzo, Alessia;Di Leo, Enza;Arca, Marcello
通讯作者：
Arca, Marcello
影响因子：
6.5
作者：
Chen, Yan Q.;Pottanat, Thomas G.;Konrad, Robert J.
通讯作者：
Konrad, Robert J.