Short-term resveratrol supplementation stimulates serum levels of bone-specific alkaline phosphatase in obese non-diabetic men
Short-term resveratrol supplementation stimulates serum levels of bone-specific alkaline phosphatase in obese non-diabetic men
复制标题
DOI：
10.1016/j.jff.2013.10.019
复制
发表时间：
2014-01-01
影响因子：
5.6
通讯作者：
Pedersen, Steen Bonlokke
中科院分区：
文献类型：
--
作者：
Poulsen, Morten Moller;Ornstrup, Marie Juul;Pedersen, Steen Bonlokke
尽管有大量的临床前证据表明多酚化合物白藜芦醇具有积极作用，但人体数据非常缺乏，目前还没有发表关于对骨代谢潜在影响的临床数据。在本研究中，我们解决了这个问题，以确定潜在的骨代谢的影响，白藜芦醇在人类受试者。在一项随机、安慰剂对照、双盲和平行组设计中，24名肥胖[BMI（kg/m2）：34.2 +/-0.7]非糖尿病男性被随机分配到500 mg白藜芦醇或安慰剂治疗组，每天三次，持续四周。在干预期前后测量骨代谢生物标志物、炎症参数和循环激素。与安慰剂组相比，白藜芦醇组骨特异性碱性磷酸酶的血浆水平显著增加[δ变化（U/l）;白藜芦醇：4.9 +/-0.6 vs.安慰剂：-1.7 +/-0.7; P <0.001]。白藜芦醇组中总碱性磷酸酶呈上升趋势（P = 0.061），而骨和钙代谢的其他生物标志物（包括PINP、骨钙素、CTx或PTH）未检测到变化。我们认为，白藜芦醇影响骨代谢，可能代表一个主要的合成代谢方式，在保持骨的完整性。然而，其临床意义仍有待评估。(C)2013爱思唯尔有限公司保留所有权利。
Despite the substantial preclinical evidence for a positive effect of the polyphenolic compound resveratrol, human data are very scarce, and currently no clinical data addressing the potential impact on bone metabolism have been published. In the present study we addressed this issue in order to identify potential bone metabolic effects of resveratrol in human subjects. In a randomised, placebo-controlled, double-blinded and parallel-group design, 24 obese [BMI (kg/m(2)): 34.2 +/- 0.7] non-diabetic men were randomly assigned to 500 mg resveratrol or placebo treatment three times daily for four weeks. Biomarkers of bone metabolism, inflammatory parameters and circulating hormones were measured before and after the intervention period. Plasma levels of bone-specific alkaline phosphatase increased significantly in the resveratrol group as compared to placebo [delta changes (U/l); resveratrol: 4.9 +/- 0.6 vs. placebo: -1.7 +/- 0.7; P < 0.001]. This was paralleled by a tendency of total alkaline phosphatase to rise within the resveratrol group (P = 0.061), whereas no changes were detected in other biomarkers of bone and calcium metabolism, including PINP, osteocalcin, CTx, or PTH. We suggest that resveratrol influences bone metabolism possibly representing a primary anabolic modality in preserving bone integrity. However, the clinical implications remain to be evaluated. (C) 2013 Elsevier Ltd. All rights reserved.