Hepatocyte growth factor demonstrates racial heterogeneity as a biomarker for coronary heart disease
Hepatocyte growth factor demonstrates racial heterogeneity as a biomarker for coronary heart disease
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DOI：
10.1136/heartjnl-2016-310450
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发表时间：
2017-08-01
期刊：
影响因子：
5.7
通讯作者：
Tsai, Michael Y.
中科院分区：
文献类型：
--
作者：
Bielinski, Suzette J.;Berardi, Cecilia;Tsai, Michael Y.
目的探讨肝细胞生长因子（hepatocyte growth factor，HGF）与亚临床和临床冠心病（CHD）的相关性。最高的平均肝细胞生长因子值（pg/mL），观察西班牙裔，其次是非洲，非西班牙裔白色，然后中国American.Results在所有种族/民族，肝细胞生长因子水平与年龄较大，较高的收缩压（SBP）和体重指数，较低的高密度脂蛋白，糖尿病和目前吸烟。在完全校正的模型中，对于非西班牙裔白人，每SD高HGF与冠状动脉钙（CAC）平均增加55 Agatston单位相关（p
Objective To determine if hepatocyte growth factor (HGF), a promising biomarker of coronary heart disease (CHD) given its release into circulation in response to endothelial damage, is associated with subclinical and clinical CHD in a racial/ethnic diverse population.Methods HGF was measured in 6738 participants of the Multi-Ethnic Study of Atherosclerosis (MESA). Highest mean HGF values (pg/mL) were observed in Hispanic, followed by African, non-Hispanic white, then Chinese Americans.Results In all races/ethnicities, HGF levels were associated with older age, higher systolic blood pressure (SBP) and body mass index, lower high-density lipoprotein, diabetes and current smoking. In fully adjusted models, each SD higher HGF was associated with an average increase in coronary artery calcium (CAC) of 55 Agatston units for non-Hispanic whites (p