Adiponectin/adiponectin receptor in disease and aging.
Adiponectin/adiponectin receptor in disease and aging.
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DOI：
10.1038/npjamd.2015.13
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发表时间：
2015
影响因子：
5
通讯作者：
Kadowaki T
中科院分区：
文献类型：
--
作者：
Iwabu M;Okada-Iwabu M;Yamauchi T;Kadowaki T
脂肪细胞不仅是能量保存的器官，而且是分泌多种生理活性物质（即脂肪因子）的内分泌器官。在这些脂肪因子中，已知脂联素通过脂联素受体 (AdipoR)、AdipoR1 和 AdipoR2 发挥抗糖尿病和抗动脉粥样硬化作用。最近还发现脂联素可以调节长寿信号，从而延长寿命。因此，激活脂联素/AdipoR信号通路的策略有望为代谢综合征、2型糖尿病和心血管疾病等肥胖相关疾病的预防和治疗以及确保人类健康长寿提供坚实的基础。
Adipocytes are not merely organs for energy conservation but endocrine organs secreting a wide array of physiologically active substances, i.e., adipokines. Of these adipokines, adiponectin is known to exert anti-diabetic and anti-atherosclerotic effects via adiponectin receptors (AdipoR)s, AdipoR1 and AdipoR2. Adiponectin has also recently been shown to regulate longevity signaling thus prolonging lifespan. Therefore, the strategy for activating adiponectin/AdipoR signaling pathways are expected to provide a solid basis for the prevention and treatment of obesity-related diseases such as the metabolic syndrome, type 2 diabetes and cardiovascular disease, as well as for ensuring healthy longevity in humans.