Phosphatase Wip1 in Immunity: An Overview and Update.
Phosphatase Wip1 in Immunity: An Overview and Update.
复制标题
免疫中的磷酸酶 Wip1：概述和更新。
DOI：
10.3389/fimmu.2017.00008
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发表时间：
2017
影响因子：
7.3
通讯作者：
Du JF
中科院分区：
文献类型：
--
作者：
Shen XF;Zhao Y;Jiang JP;Guan WX;Du JF
野生型p53诱导的磷酸酶1（Wild-type p53-induced phosphatase 1，Wip 1）是一种新发现的丝氨酸/苏氨酸磷酸酶，属于PP 2C家族。由于Wip 1参与应激诱导的网络和人类肿瘤中的过度表达，主要研究主要集中在Wip 1在肿瘤发生中的作用。现在它也参与调节其他几个生理过程，如生物体衰老和神经发生。最近的证据强调了Wip 1通过调节免疫细胞发育和功能以及通过与炎症信号通路如NF-κB和p38丝裂原活化蛋白激酶的相互作用来控制免疫应答的新作用。在这篇简短的综述中，我们将概述Wip 1在免疫中的作用，以更好地了解这一重要的磷酸酶。
Wild-type p53-induced phosphatase 1 (Wip1) is a newly identified serine/threonine phosphatase, which belongs to the PP2C family. Due to its involvement in stress-induced networks and overexpression in human tumors, primary studies have mainly focused on the role of Wip1 in tumorigenesis. It now has also been implicated in regulating several other physiological processes such as organism aging and neurogenesis. Recent evidence highlights a new role of Wip1 in controlling immune response through regulating immune cell development and function, as well as through the interplay with inflammatory signaling pathways such NF-κB and p38 mitogen-activated protein kinase. In this short review, we will give an overview of Wip1 in immunity to better understand this important phosphatase.