Maspin expression patterns differ in the invasive versus lepidic growth pattern of pulmonary adenocarcinoma.
Maspin expression patterns differ in the invasive versus lepidic growth pattern of pulmonary adenocarcinoma.
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DOI：
10.1111/his.12485
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发表时间：
2014-12
期刊：
影响因子：
6.4
通讯作者：
Sheng S
中科院分区：
文献类型：
--
作者：
Lonardo F;Guan H;Dzinic S;Sheng S
为了测试maspin亚细胞定位的变化是否平行于肺腺癌的形态进展，我们比较了其在麻风性和侵袭性生长模式中的表达。应用免疫组织化学方法，我们比较了不同肿瘤(系列1，n=586)以及同一肿瘤内和同一切片(系列#2，n=629)中发生的恶性和侵袭性生长模式中maspin的表达。在这两个系列中，麻风性生长模式(n=45)与核maspin显著相关，而侵袭性(n=470)核和胞浆maspin相结合(P<0.05)。在第二个系列中，同一肿瘤从麻风型向侵袭型的转变主要与核转移到核浆maspin结合(15/29)或保留核表达(8/29)有关。核型maspin表达由阴性转变为阴性(3/29)或其他改变(3/29)。核型maspin是肺腺癌典型的但不是唯一的特征，而核型和胞浆maspin的结合则是侵袭性的特征。这些数据表明，maspin的表达和亚细胞定位的变化可能构成肿瘤进展的重要生物学终点，并有助于肺腺癌的分类。
To test whether changes in the subcellular localization of maspin parallel morphological progression in pulmonary adenocarcinoma, we compared its expression between lepidic and invasive growth patterns. Applying immunohistochemistry, we compared maspin expression in lepidic and invasive growth patterns occurring in different tumours (series #1, n = 86) as well as within the same tumour and in the same section (series #2, n = 29). In both series, the lepidic growth pattern (n = 45) was significantly associated with nuclear maspin, while the invasive (n = 70) with combined nuclear and cytoplasmic maspin (P < 0.05). In the second series, transition from a lepidic to an invasive pattern in the same tumour was associated predominantly with a shift respectively from a nuclear to a combined nuclear and cytoplasmic maspin (15/29) or preservation of nuclear expression (8/29). A shift from nuclear maspin to negative expression (3/29) or other patterns (3/29) were also observed. Nuclear maspin is a typical but not exclusive feature of the lepidic growth pattern of pulmonary adenocarcinoma, whereas combined nuclear and cytoplasmic maspin characterizes invasion. These data show that changes of expression and subcellular localization of maspin may constitute an important biological end point of tumour progression and aid in the classification of lung adenocarcinoma.
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DOI：
10.1097/pas.0b013e318190157c
发表时间：
2009-03
期刊：
The American journal of surgical pathology
影响因子：
--
作者：
Borczuk AC;Qian F;Kazeros A;Eleazar J;Assaad A;Sonett JR;Ginsburg M;Gorenstein L;Powell CA
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Powell CA
DOI：
10.3233/cbm-2011-0166
发表时间：
2010
期刊：
Cancer biomarkers : section A of Disease markers
影响因子：
--
作者：
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Brambilla E
影响因子：
168.9
作者：
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通讯作者：
Shepherd, Frances A.
影响因子：
8
作者：
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通讯作者：
Besson, A.
DOI：
10.1038/modpathol.2012.106
发表时间：
2012-12
期刊：
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
影响因子：
--
作者：
Thunnissen E;Beasley MB;Borczuk AC;Brambilla E;Chirieac LR;Dacic S;Flieder D;Gazdar A;Geisinger K;Hasleton P;Ishikawa Y;Kerr KM;Lantejoul S;Matsuno Y;Minami Y;Moreira AL;Motoi N;Nicholson AG;Noguchi M;Nonaka D;Pelosi G;Petersen I;Rekhtman N;Roggli V;Travis WD;Tsao MS;Wistuba I;Xu H;Yatabe Y;Zakowski M;Witte B;Kuik DJ
通讯作者：
Kuik DJ