Cyclo‐oxygenase‐1 or ‐2‐mediated metabolism of arachidonic acid in endothelium‐dependent contraction of mouse arteries
Cyclo‐oxygenase‐1 or ‐2‐mediated metabolism of arachidonic acid in endothelium‐dependent contraction of mouse arteries
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DOI：
10.1113/expphysiol.2013.072017
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发表时间：
2013-07
影响因子：
2.7
通讯作者：
Yingbi Zhou;Wenhong Luo;Yingzhan Zhang;Hui Li;Dongyang Huang;B. Liu
中科院分区：
文献类型：
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作者：
Yingbi Zhou;Wenhong Luo;Yingzhan Zhang;Hui Li;Dongyang Huang;B. Liu
·本研究的中心问题是什么？确定参与内皮依赖性收缩的特异性环加氧酶（考克斯）亚型，以及是否可以在中膜平滑肌中由可能从内皮扩散的前列腺素H2生成前列腺素I2（内皮源性血管收缩活性的介质）。·主要发现及其重要性是什么？我们的研究结果证明了考克斯-1在花生四烯酸代谢中的主要作用，并表明在给定的小鼠动脉中，来自考克斯亚型的代谢物引起收缩。此外，我们的研究结果表明，参与内皮考克斯介导的代谢的血管收缩活性的一些前列腺素I2可能是由中膜平滑肌中的前列腺素H2产生的。这些发现增加了我们目前对内皮依赖性收缩机制的理解。
• What is the central question of this study? To determine the specific cyclo‐oxygenase (COX) isoform(s) involved in endothelium‐dependent contraction and whether prostaglandin I2, a mediator of endothelium‐derived vasoconstrictor activity, can be generated in medial smooth muscle from prostaglandin H2 that might diffuse from the endothelium. • What is the main finding and its importance? Our results demonstrate a predominant role for COX‐1 in arachidonic acid metabolism and suggest that in the given mouse arteries, metabolites from either COX isoform cause contraction. Moreover, our results imply that some of the prostaglandin I2 involved in the vasoconstrictor activity of endothelial COX‐mediated metabolism could possibly be generated from prostaglandin H2 in the medial smooth muscle. These findings add to our current understanding of mechanisms for endothelium‐dependent contraction.