Genetic management strategies for controlling infectious diseases in livestock populations
Genetic management strategies for controlling infectious diseases in livestock populations
复制标题
DOI：
10.1051/gse:2003013
复制
发表时间：
2003-01-01
影响因子：
4.1
通讯作者：
MacKenzie, KA
中科院分区：
文献类型：
--
作者：
Bishop, SC;MacKenzie, KA
本文考虑使用抗病基因来控制动物群体中的感染传播。传播情况用 R-0 来概括，即病原体的基本繁殖率。如果 R-0 > 1.0，可能会发生重大流行病，因此疾病控制策略应旨在将 R-0 降低到 1.0 以下，例如通过与易感野生型动物混合产生耐药性。假设存在抗性等位基因，则通过该等位基因纯合群体的感染传播将是 R-02 < R-01，其中 R-01 描述了野生型群体中的传播。对于由这两组动物组成的同质群体，R-0 是两个亚群体的加权平均值：R-0 = R-01 rho + R-02 (1 - rho)，其中 p 是野生型动物的比例。如果 R-01 > 1 且 R-02 < 1，则两种基因型的比例应使得 R-0
This paper considers the use of disease resistance genes to control the transmission of infection through an animal population. Transmission is summarised by R-0, the basic reproductive ratio of a pathogen. If R-0 > 1.0 a major epidemic can occur, thus a disease control strategy should aim to reduce R-0 below 1.0, e.g. by mixing resistant with susceptible wild-type animals. Suppose there is a resistance allele, such that transmission of infection through a population homozygous for this allele will be R-02 < R-01, where R-01 describes transmission in the wildtype population. For an otherwise homogeneous population comprising animals of these two groups, R-0 is the weighted average of the two sub-populations: R-0 = R-01 rho + R-02 (1 - rho), where p is the proportion of wildtype animals. If R-01 > 1 and R-02 < 1, the proportions of the two genotypes should be such that R-0