Regulation of human T cell leukemia virus expression 1
Regulation of human T cell leukemia virus expression 1
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人T细胞白血病病毒表达的调控1
DOI：
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发表时间：
1990
期刊：
影响因子：
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通讯作者：
I. Chen
中科院分区：
文献类型：
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作者：
P. Green;I. Chen
C型形态的逆转录病毒与动物和人类的多种疾病有关。人类T细胞白血病病毒I型（HTLV-I）和II型（HTLV-II），原型人类C型逆转录病毒，已被确定为某些形式的人类白血病和神经系统疾病的病原体。HTLV的遗传结构和调控比它们的禽类和小鼠白血病病毒对应物更复杂。除了编码所有可复制逆转录病毒的特征性病毒体蛋白的gag、pol和env基因外，HTLV的基因组编码调节病毒基因表达所需的非结构蛋白Tax和雷克斯。为了理解HTLV诱导疾病的复杂机制，阐明病毒基因产物的调节和功能以及这些产物彼此之间以及与细胞因子的相互作用将是至关重要的。这篇综述主要集中在受感染的人T淋巴细胞中HTLV基因表达的调控，但也讨论了人类免疫缺陷病毒（HIV）的类似基因调控。它特别关注这些基因产物在病毒复制和最终发病机制中的作用。绿色，P. L.;陈岛，澳-地S. Y.人T细胞白血病病毒表达的调控。FASEB J. 4：169 - 175; 1990.
Retroviruses of the type C morphology have been implicated in a wide variety of diseases in animals and humans. The human T cell leukemia viruses types I (HTLV‐I) and II (HTLV‐II), the prototypic human‐type C retroviruses, have been identified as the causative agents of some forms of human leukemia and neurological disorders. The genetic structure and regulation of the HTLVs are more complex than their avian and murine leukemia virus counterparts. In addition to the gag, pol, and env genes that encode the characteristic virion proteins of all replication competent retroviruses, the genomes of HTLV encode the nonstructural proteins, Tax and Rex, which are required for regulating viral gene expression. To understand what appears to be a complex mechanism of disease induction by HTLV, elucidating the regulation and function of the viral gene products and the interaction of these products with each other, as well as with cellular factors, will be critical. This review focuses primarily on regulation of HTLV gene expression in the infected human T lymphocyte, but also discusses analogous gene regulation by the human immunodeficiency virus (HIV). It concentrates specifically on the role these gene products play in virus replication and, ultimately, pathogenesis.—Green, P. L.; Chen, I. S. Y. Regulation of human T cell leukemia virus expression. FASEB J. 4: 169‐175; 1990.