Obesity-Associated Hypertension: the Upcoming Phenotype in African-American Women

Obesity-Associated Hypertension: the Upcoming Phenotype in African-American Women
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肥胖相关高血压:非洲裔美国女性即将出现的表型

DOI:
10.1007/s11906-017-0738-x
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发表时间:
2017
影响因子:
5.6
通讯作者:
S. Oparil
S. Oparil
中科院分区:
医学2区
文献类型:
--
作者:
R. Samson;Andrea Qi;Abhishek Jaiswal;T. L. Le Jemtel;S. Oparil

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目前肥胖症的流行特别影响非洲裔美国妇女。肥胖症的流行是否会改变高血压表型在African-American women是entertained.Recent FindingsThe患病率的病态肥胖是稳步增加的非裔美国妇女,谁是容易发展高血压(HTN),即使在没有肥胖。肥胖相关性高血压表型的特征在于显著的交感神经系统激活和对抗高血压治疗的抵抗/不应性。通过生活方式干预和药物治疗实现的体重减轻具有适度且很少持续的抗高血压作用。相比之下,减肥手术具有持续的降压效果,证明了正常化的高血压或减轻抗高血压therapy.SummaryThe患病率的HTN及其肥胖相关的表型很可能会增加在非洲裔美国妇女在未来几十年。肥胖的非洲裔美国妇女可能会越来越多地提到减肥手术时,高血压仍然不受控制,尽管生活方式干预和药物治疗的体重减轻和血压(BP)控制。
Purpose of ReviewThe present obesity epidemic particularly affects African-American women. Whether the obesity epidemic will alter the hypertension phenotype in African-American women is entertained.Recent FindingsThe prevalence of morbid obesity is steadily increasing in African-American women, who are prone to developing hypertension (HTN) even in the absence of obesity. The obesity-associated hypertension phenotype is characterized by marked sympathetic nervous system activation and resistance/refractoriness to antihypertensive therapy. Weight loss achieved through lifestyle interventions and pharmacotherapy has a modest and rarely sustained antihypertensive effect. In contrast, bariatric surgery has a sustained antihypertensive effect, as evidenced by normalization of hypertension or lessening of antihypertensive therapy.SummaryThe prevalence of HTN and its obesity-associated phenotype is likely to increase in African-American women over the next decades. Obese African-American women may be increasingly referred for bariatric surgery when hypertension remains uncontrolled despite lifestyle interventions and pharmacological therapy for weight loss and blood pressure (BP) control.
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