Obesity-Associated Hypertension: the Upcoming Phenotype in African-American Women
Obesity-Associated Hypertension: the Upcoming Phenotype in African-American Women
复制标题
肥胖相关高血压:非洲裔美国女性即将出现的表型
DOI:
10.1007/s11906-017-0738-x
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发表时间:
2017
影响因子:
5.6
通讯作者:
S. Oparil
中科院分区:
文献类型:
--
作者:
R. Samson;Andrea Qi;Abhishek Jaiswal;T. L. Le Jemtel;S. Oparil
Purpose of ReviewThe present obesity epidemic particularly affects African-American women. Whether the obesity epidemic will alter the hypertension phenotype in African-American women is entertained.Recent FindingsThe prevalence of morbid obesity is steadily increasing in African-American women, who are prone to developing hypertension (HTN) even in the absence of obesity. The obesity-associated hypertension phenotype is characterized by marked sympathetic nervous system activation and resistance/refractoriness to antihypertensive therapy. Weight loss achieved through lifestyle interventions and pharmacotherapy has a modest and rarely sustained antihypertensive effect. In contrast, bariatric surgery has a sustained antihypertensive effect, as evidenced by normalization of hypertension or lessening of antihypertensive therapy.SummaryThe prevalence of HTN and its obesity-associated phenotype is likely to increase in African-American women over the next decades. Obese African-American women may be increasingly referred for bariatric surgery when hypertension remains uncontrolled despite lifestyle interventions and pharmacological therapy for weight loss and blood pressure (BP) control.
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影响因子:
120.7
作者:
Whelton, PK;Appel, LJ;Cutler, JA
通讯作者:
Cutler, JA
影响因子:
20.1
作者:
Wolfe BM;Kvach E;Eckel RH
通讯作者:
Eckel RH
DOI:
10.1152/ajprenal.00265.2015
发表时间:
2016
期刊:
American journal of physiology. Renal physiology
影响因子:
--
作者:
Nizar,JonathanM;Dong,Wuxing;McClellan,RobertB;Labarca,Mariana;Zhou,Yuehan;Wong,Jared;Goens,DonaldG;Zhao,Mingming;Velarde,Nona;Bernstein,Daniel;Pellizzon,Michael;Satlin,LisaM;Bhalla,Vivek
通讯作者:
Bhalla,Vivek
影响因子:
120.7
作者:
Agodoa, LY;Appel, L;Xu, SC
通讯作者:
Xu, SC
影响因子:
24
作者:
Vorsanger,MatthewH;Subramanyam,Pritha;Weintraub,HowardS;Lamm,StevenH;Underberg,JamesA;Gianos,Eugenia;Goldberg,IraJ;Schwartzbard,ArthurZ
通讯作者:
Schwartzbard,ArthurZ