Effect of Sit-Stand Maneuver on Baroreflex Sensitivity and Cardiovascular Disease Risk Assessments.
Effect of Sit-Stand Maneuver on Baroreflex Sensitivity and Cardiovascular Disease Risk Assessments.
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坐站动作对压力反射敏感性和心血管疾病风险评估的影响。
DOI：
10.1152/ajpregu.00141.2021
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发表时间：
2022
期刊：
影响因子：
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通讯作者：
Seiji Maeda.
中科院分区：
文献类型：
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作者：
Shoya Mori;Takashi Tarumi;Keisei Kosaki;Masahiro Matsui;Masaki Yoshioka;Jun Sugawara;Makoto Kuro-o;Chie Saito;Kunihiro Yamagata;Seiji Maeda.
在生理学研究中，坐立动作（SSM）越来越多地用于压力反射敏感性（BRS）的测量，但尚不清楚需要进行多少SSM来测量BRS并评估其与心血管疾病（CVD）风险的关系。因此，本研究旨在确定1）SSM重复次数对BRS的影响，以及2）BRS与CVD危险因素之间的关联。在5分钟的自发休息和5分钟的0.05 Hz（即，15个周期的10-s坐和10-s站）。在SSM期间，使用心率（HR）和收缩压（SBP）的传递函数分析，根据3、6、9、12和15个SSM的增量周期计算BRS。测量一般CVD危险因素、颈动脉硬度和心肺功能。结果显示，在SSMs期间HR和SBP增加（P< 0.05）。在静息和SSM条件下，BRS保持在相似的水平，而相干函数在3个周期的SSM后达到峰值。有≥6个周期SSM的BRS与年龄（r=-0.721 ~-0.740）、颈动脉扩张性（r= 0.625-0.629）和心肺适应性（r= 0.333-0.351）密切相关（均P < 0.001）。多元回归分析表明，BRS与≥6个周期的SSM解释>60%的CVD危险因素的方差。因此，我们的研究结果表明，重复的SSM显着加强BRS和CVD危险因素之间的关联。特别是，具有≥6个周期SSM的BRS与CVD风险密切相关。
Sit-stand maneuvers (SSMs) have increasingly been used for baroreflex sensitivity (BRS) measurement in physiological research, but it remains unknown as to how many SSMs need to be performed to measure BRS and assess its relationship with cardiovascular disease (CVD) risk. Therefore, this study aimed to determine1) the effect of the number of SSM repetitions on BRS, and2) the association between BRS and CVD risk factors. Data were collected from 174 individuals during 5 min of spontaneous rest and 5 min of repeated SSMs at 0.05 Hz (i.e., 15 cycles of 10-s sit and 10-s stand). During SSMs, BRS was calculated from the incremental cycles of 3, 6, 9, 12, and 15 SSMs using transfer function analysis of heart rate (HR) and systolic blood pressure (SBP). General CVD risk factors, carotid arterial stiffness, and cardiorespiratory fitness were measured. In result, HR and SBP increased during SSMs (P< 0.05). The BRS remained at a similar level during the resting and SSM conditions, whereas the coherence function reached its peak after 3 cycles of SSMs. BRS with ≥6 cycles of SSMs was strongly correlated with age (r= −0.721 to −0.740), carotid distensibility (r= 0.625–0.629), and cardiorespiratory fitness (r= 0.333–0.351) (allP< 0.001). Multiple regression analysis demonstrated that BRS with ≥6 cycles of SSMs explained >60% of the variance in CVD risk factors. Therefore, our findings suggest that repeated SSMs significantly strengthens the association between BRS and CVD risk factors. Particularly, BRS with ≥6 cycles of SSMs is strongly associated with CVD risk.