Lesions of suprachiasmatic nucleus efferents selectively affect rest-activity rhythm
Lesions of suprachiasmatic nucleus efferents selectively affect rest-activity rhythm
复制标题
DOI：
10.1016/j.mce.2006.03.036
复制
发表时间：
2006-06-27
影响因子：
4.1
通讯作者：
Moore, Robert Y.
中科院分区：
文献类型：
--
作者：
Abrahamson, Eric E.;Moore, Robert Y.
下丘脑的视交叉上核（SCN）控制行为、神经内分泌和生理功能的昼夜节律。在这项研究中，我们测试的假设，尾侧SCN的室旁下区（SPVZ）的传出控制的节奏在休息活动（R-A）通过预测后下丘脑区唤醒系统（PHA）。腹侧SPVZ的小电解质损伤导致昼夜R-A节律的选择性丧失，保留了核心体温节律。相反，下丘脑后区（PHA）的大的兴奋性毒性病变有效地消融了投射到皮质和皮质下唤醒区的下丘脑泌素和黑色素集中激素神经元的群体，降低了R-A节律幅度，但不破坏昼夜节律调节。由于下丘脑背内侧核损伤具有与PHA损伤相似的作用（Chou，T.C.，Scammell，T. E.，古利，J. J.，Gans，S.E.，Saper，C. B.，卢，J，2003.下丘脑背内侧核在广泛的行为昼夜节律中的关键作用。神经科学杂志23：10691-10702），这些数据支持SPVZ是SCN信号到参与R-A节律产生的多个后下丘脑唤醒系统的主要中继核的观点。(c)2006爱思唯尔爱尔兰有限公司保留所有权利。
The suprachiasmatic nucleus (SCN) of the hypothalamus controls circadian rhythms in behavioral, neuroendocrine and physiological functions. In this study, we test the hypothesis that caudal SCN efferents to the subparaventricular zone (SPVZ) control the rhythm in rest-activity (R-A) through projections on posterior hypothalamic area arousal systems (PHA). Small electrolytic lesions of the ventral SPVZ cause a selective loss of the circadian R-A rhythm, sparing the core body temperature rhythm. In contrast, large excitotoxic lesions of the posterior hypothalamic area (PHA) that effectively ablate populations of hypocretin and melanin concentrating hormone neurons projecting to cortex and subcortical arousal areas decrease R-A rhythm amplitude but do not disrupt circadian regulation. Since dorsomedial hypothalamic nucleus lesions have effects similar to PHA lesions (Chou, T.C., Scammell, T.E., Gooley, J.J., Gans, S.E., Saper, C.B., Lu, J., 2003. Critical role of dorsomedial hypothalamic nucleus in a wide range of behavioral circadian rhythms. J. Neurosci. 23:10691-10702), these data support the view that the SPVZ is the principal relay nucleus for SCN signals to the multiple posterior hypothalamic arousal systems involved in generation of the R-A rhythm. (c) 2006 Elsevier Ireland Ltd. All rights reserved.