Factors associated with a delay in the diagnosis of narcolepsy
Factors associated with a delay in the diagnosis of narcolepsy
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DOI：
10.1016/j.sleep.2003.06.002
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发表时间：
2004-01-01
期刊：
影响因子：
4.8
通讯作者：
Shneerson, JM
中科院分区：
文献类型：
--
作者：
Morrish, E;King, MA;Shneerson, JM
背景：发作性睡病从症状出现到诊断可能有很长的间隔。文献中没有多变量分析报告可能导致这种延迟的因素。本研究的目的是描述在诊断的人与嗜睡症生活在英国的延迟，并确定相关factors.Methods：这项研究包括一个邮政调查的500名成员的嗜睡症协会英国，其中包括有关症状的发病年龄，年的诊断和受试者的人口统计学问题。结果：共回收问卷313份，其中219份已完成，足以进行分析。症状发作和诊断之间的间隔范围为1至61年，中位数为10.5年。多变量分析表明，作为初始症状之一的突然倒的存在和最近一年出现症状是与诊断时间相关的唯一因素。结论：我们已经证实，发作性睡病的诊断可以推迟多年，特别是当最初没有突然倒时。在英国，诊断延迟似乎正在减少，这可能是由于医生和患者对发作性睡病临床表现的认识提高。(C)2003 Elsevier B.V.保留所有权利。
Background: There can be a long interval from the onset of symptoms before a diagnosis of narcolepsy is made. There are no multivariate analyses reported in the literature of factors that may contribute to this delay. The aims of this study were to describe the delay in diagnosis of people with narcolepsy living in the UK and to identify associated factors.Methods: The study comprised a postal survey of 500 members of the Narcolepsy Association UK, which included questions regarding age of onset of symptoms, year of diagnosis and subject demographics. Cox's proportional hazards regression was performed.Results: A total of 313 questionnaires were returned of which 219 had been completed sufficiently for analysis. The interval between symptom onset and diagnosis ranged from within 1 to 61 years with a median of 10.5 years. Multivariate analysis showed that the presence of cataplexy as one of the initial symptoms and a more recent year of symptom onset were the only factors associated with time to diagnosis.Conclusions: We have confirmed that the diagnosis of narcolepsy can be delayed for many years particularly when cataplexy is absent initially. The delay in diagnosis in the UK appears to be decreasing, probably through greater doctor and patient awareness of the clinical manifestations of narcolepsy. (C) 2003 Elsevier B.V. All rights reserved.