Crucial Role of CGI-58/α/β Hydrolase Domain-Containing Protein 5 in Lipid Metabolism
Crucial Role of CGI-58/α/β Hydrolase Domain-Containing Protein 5 in Lipid Metabolism
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DOI：
10.1248/bpb.33.342
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发表时间：
2010-03
影响因子：
2
通讯作者：
Tomohiro Yamaguchi
中科院分区：
文献类型：
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作者：
Tomohiro Yamaguchi
脂滴表面是细胞内脂质聚集和降解调控的主要部位，在全身脂质稳态中起着重要作用。CGI-58（又称α/β水解酶结构域蛋白5 (ABHD5)）是α/β水解酶蛋白家族的成员，是以甘油三酯（TG）在各组织中过度储存为特征的Chanarin-Dorfman综合征（CDS）致病基因的产物。CGI-58主要分布在ld表面，在细胞TG降解中起关键作用。在脂肪分解过程中，CGI-58与几种蛋白质协同作用，包括PAT蛋白家族成员perilipin和脂肪甘油三酯脂肪酶（ATGL），这是一种被认为是脂肪细胞中TG降解的限速酶。除了在脂肪细胞中发挥作用外，CGI-58还参与多种组织的脂质降解，包括皮肤和肝脏组织。本文就肝组织表面CGI-58在调节细胞脂肪动员中的作用及蛋白相互作用作一综述。
The surfaces of lipid droplets (LDs) constitute major sites of regulated accumulation and degradation of lipid in cells, and hence play important roles in lipid homeostasis of the whole body. CGI-58 (also called α/β hydrolase domain-containing protein 5 (ABHD5)) is a member of the α/β-hydrolase family of proteins and is a product of the causal gene of Chanarin–Dorfman syndrome (CDS), which is characterized by excessive storage of triacylglycerol (TG) in various tissues. CGI-58 is distributed predominantly on the surface of LDs and plays a crucial role in TG degradation in cells. In the process of lipolysis, CGI-58 coordinates with several proteins, including perilipin, a member of the PAT family of proteins, and adipose triglyceride lipase (ATGL), a putative rate-limiting enzyme for TG degradation in adipocytes. Besides its role in adipocytes, CGI-58 is involved in lipid degradation in various tissues, including those of skin and liver. This review focuses on the functions and protein interactions of CGI-58 on the surface of LDs in the regulation of fat mobilization in cells.