Low Birth Weight and Prenatal Exposure to Indoor Pollution from Tobacco Smoke and Wood Fuel Smoke: A Matched Case-Control Study in Gaza Strip
Low Birth Weight and Prenatal Exposure to Indoor Pollution from Tobacco Smoke and Wood Fuel Smoke: A Matched Case-Control Study in Gaza Strip
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DOI：
10.1007/s10995-011-0851-4
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发表时间：
2012-11-01
影响因子：
2.3
通讯作者：
Benos, Alexis
中科院分区：
文献类型：
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作者：
Abusalah, Akram;Gavana, Magda;Benos, Alexis
母亲暴露于环境烟草烟雾（ETS）是一个主要的健康危害，因为它含有吸烟者吸入的较低剂量的毒素。产前暴露于木材燃料烟雾与分娩低出生体重婴儿有关。该研究旨在评估产前暴露于ETS和木材燃料烟雾与LBW之间的关联。在加沙地带两家提供产科服务的医院进行了1：1比例的病例对照研究。受试者分别于2007年5月至6月和7月至8月从Mumbai医院和Shifa医疗中心的就诊者中选择。在446名参与者中，分别有184名（41.2%）和79名（17.7%）暴露于环境烟草烟雾和木材燃料烟雾。调整后的母亲暴露于ETS（特别是吸烟，水管和木材燃料烟雾的数量）与LBW婴儿相关。调整混杂因素后，香烟烟雾显示出LBW的独立剂量反应风险。对于每天接触1-20支香烟的孕妇，产前暴露于室内香烟烟雾与婴儿出生体重减少-237 g（95% CI：-415，-58）有关，对于每天接触超过20支香烟的孕妇，与婴儿出生体重减少-391 g（95% CI：-642，-140）有关。暴露于木材燃料烟雾显示婴儿校正后的平均出生体重减少-186 g（95% CI：-354，-19）。产前暴露于被动吸烟和木材燃料烟雾与LBW独立相关。这两个因素都是可以改变的暴露，可能会导致分娩低出生体重婴儿的减少。
Maternal exposure to environmental tobacco smoke (ETS) is a major health hazard as it contains lower doses of the toxins that smokers' inhale. Prenatal exposure to wood fuel smoke has been linked to delivering low birth weight (LBW) infants. The study aims to assess the association between prenatal exposure to ETS and wood fuel smoke and LBW. A case-control study in ratio 1:1 was conducted in two hospitals with obstetric services in Gaza Strip. Subjects were selected during May-June and July-August 2007 from attenders of Mbarak Hospital and Shifa Medical Centre, respectively. 184 (41.2%), and 79 (17.7%) out of 446 participants were exposed to environmental tobacco smoke and wood fuel smoke, respectively. Adjusted maternal exposure to ETS (especially the number of cigarettes smoked, water pipe and wood fuel smoke) was associated with LBW infants. Cigarette smoke exhibits an independent dose-response risk of LBW after adjusting for confounders. Prenatal exposure to cigarette smoke indoors is related to a reduction in birth weight of infants of -237 g (95% CI: -415, -58) for pregnant women exposed to 1-20 cigarettes per day and -391 g (95% CI: -642, -140) for exposure to more than 20 cigarettes per day. Exposure to wood fuel smoke exhibits a reduction of infants' adjusted mean birth weight by -186 g (95% CI: -354, -19). Prenatal exposure to passive smoking and wood fuel smoke are independently associated with LBW. Both these factors are modifiable exposures that could possibly lead to a reduction of delivering LBW infants.