Human papillomavirus genotype distribution in external acuminata condylomata:: A large French national study (EDiTH IV)
Human papillomavirus genotype distribution in external acuminata condylomata:: A large French national study (EDiTH IV)
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DOI：
10.1086/590560
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发表时间：
2008-09-01
影响因子：
11.8
通讯作者：
Riethmuller, Didier
中科院分区：
文献类型：
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作者：
Aubin, Francois;Pretet, Jean-Luc;Riethmuller, Didier
背景。外部尖锐湿疣（EAC）是最常见的性传播疾病之一。尽管众所周知，低风险人乳头瘤病毒 (HPV) 基因型 6 和 11 与 EAC 相关，但只有少数小型已发表的研究报告了 HPV 基因型特异性患病率。我们研究的目的是评估涉及男性和女性的大量病例中 HPV 基因型的流行情况，并评估法国四价（基因型 6、11、16 和 18）HPV 疫苗的潜在益处。方法。 2007 年 1 月至 4 月期间，前瞻性招募了 256 名女性和 260 名男性向法国妇科医生、皮肤科医生和直肠科医生提出 EAC。用细胞刷收集样本，并使用 INNO-LiPA 检测 (Innogenics) 测定 HPV 基因型，该检测可检测 24 种 HPV 基因型。结果。可以分析四百二十三个β珠蛋白阳性样本。患者的中位年龄为 30 岁（范围：18-72 岁）。 EAC 患者中 HPV DNA 的总体患病率为 99%（33% 的患者同时感染另一种病原体）。低风险基因型占主导地位，患病率为 89%。最常见的基因型是 6 (69%) 和 11 (16%)，其次是 16 (9%)、51 (8%)、52 (7%)、66 (6%)、53 (5%)、31 (3%) 和 18 (3%)。基因型6和11的累积患病率为83%，基因型6、11、16和18的累积患病率为88%。结论。据我们所知，这项研究是第一个大型多中心调查，旨在提供 EAC 患者中 HPV 基因型分布的可靠数据。我们的研究结果提供了强有力的证据，表明在法国，EAC 患者中最常见的 HPV 基因型是 6 型和 11 型。由于四价 HPV 疫苗预防 EAC 的功效高达 99%，且疫苗覆盖率为 100%，因此可以预防法国 62%-87% 的 EAC 病例。
Background. External acuminata condylomata (EAC) are among the most common sexually transmitted diseases. Although it is understood that low-risk human papillomavirus (HPV) genotypes 6 and 11 are associated with EAC, there have only been a few, small, published studies reporting the genotype-specific prevalence of HPV. The objective of our study was to assess the prevalence of HPV genotypes for a large number of cases involving both men and women and to evaluate the potential benefit of a quadrivalent (genotypes 6, 11, 16, and 18) HPV vaccine in France.Methods. A total of 256 women and 260 men who presented with EAC to French gynecologists, dermatologists, and proctologists were prospectively recruited during the period January through April 2007. Specimens were collected with a cytobrush, and the HPV genotype was determined using the INNO-LiPA assay (Innogenetics), which detects 24 HPV genotypes.Results. Four hundred twenty-three beta-globin-positive samples could be analyzed. The median age of patients was 30 years (range, 18-72 years). The overall prevalence of HPV DNA in patients with EAC was 99% (33% of patients were coinfected with another pathogen). Low-risk genotypes predominated, with a prevalence of 89%. The most prevalent genotypes were 6 (69%) and 11 (16%), followed by 16 (9%), 51 (8%), 52 (7%), 66 (6%) 53 (5%), 31 (3%), and 18 (3%). The cumulative prevalence of genotypes 6 and 11 was 83%, and the cumulative prevalence of genotypes 6, 11, 16, and 18 was 88%.Conclusions. This study is, to our knowledge, the first large, multicenter survey to provide solid data on HPV genotype distribution among patients with EAC. Our results provide strong evidence that, in France, the most prevalent HPV genotypes in persons with EAC are 6 and 11. Because of its 99% efficacy for the prevention of EAC and a vaccine coverage of 100%, the quadrivalent HPV vaccine could prevent 62%-87% of EAC cases in France.