Antioxidants: Their Role in Pregnancy and Miscarriage
Antioxidants: Their Role in Pregnancy and Miscarriage
复制标题
DOI：
10.1089/15230860050192369
复制
发表时间：
2000-09-01
影响因子：
6.6
通讯作者：
Walker, James J.
中科院分区：
文献类型：
--
作者：
Jenkins, Carol;Wilson, Rhoda;Walker, James J.
这项研究的目的是检查抗氧化剂在正常月经周期，健康怀孕和早期流产妇女中的作用。抗氧化剂的选择包括两个从外周血血浆巯基和铜蓝蛋白和两个细胞外参数超氧化物歧化酶（SOD）和红细胞溶解产物巯基。我们发现，抗氧化剂水平在整个月经周期变化不大。成功足月的妊娠与妊娠早期血浆铜蓝蛋白和SOD水平升高有关。这些变化被认为可以保护细胞免受与怀孕相关的氧化应激增加所造成的损害。早期妊娠流产与SOD水平显著降低有关。在第一次怀孕中流产但第二次怀孕成功的患者亚组中，与流产时的水平相比，正在进行的妊娠中血浆巯基水平较高，红细胞裂解物巯基水平显著降低。流产和怀孕似乎与氧化应激增加有关。然而，在成功的妊娠中，外周血发生了变化，提供了对氧化剂攻击的保护。抗氧化剂氧化还原信号。2，623-628。
The aim of this study was to examine the role of antioxidants within the normal menstrual cycle, in healthy pregnancy, and in women suffering first-trimester miscarriage. The antioxidants chosen comprised of two from peripheral blood-plasma thiol and ceruloplasmin-and two extracellular parameters-superoxide dismustase (SOD) and red cell lysate thiol. We found that antioxidant levels varied little throughout the menstrual cycle. Pregnancies that went successfully to term were associated with increased levels of ceruloplasmin and SOD early in the first trimester. These changes were thought to offer the cell protection from the damage caused by the increased oxidative stress associated with pregnancy. First-trimester miscarriage was associated with significantly reduced levels of SOD. A subgroup of patients who miscarried in their first pregnancy, but whose second pregnancies were successful, had higher levels of plasma thiol and significantly reduced levels of red cell lysate thiol in the on-going pregnancy compared to levels at the time of miscarriage. Miscarriage and pregnancy appear to be associated with increased oxidative stress. In a successful pregnancy, however, changes occurred within the peripheral blood that offered protection from oxidant attack. Antiox. Redox Signal. 2, 623-628.