Accurate prediction of HbA1c by continuous glucose monitoring using a kinetic model with patient-specific parameters for red blood cell lifespan and glucose uptake.
Accurate prediction of HbA1c by continuous glucose monitoring using a kinetic model with patient-specific parameters for red blood cell lifespan and glucose uptake.
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DOI：
10.1177/14791641211013734
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发表时间：
2021-05
影响因子：
2.4
通讯作者：
Dunn TC
中科院分区：
文献类型：
--
作者：
Xu Y;Hirota Y;Ajjan RA;Yamamoto A;Matsuoka A;Ogawa W;Dunn TC
最近的一个动力学模型提出了一个新的个体化血糖标志物，计算HbA1c(CHbA1c)，基于每个人特有的动力学参数和血糖水平。当前工作的目的是验证这种用于临床的血糖测量的准确性，并评估估计个人运动因素的数据要求。我们检索了51例接受传感器增强泵(SAP)治疗的日本T1D患者的糖化血红蛋白和血糖数据。数据部分确定了两个患者特有的动力学参数，定义为两个实验室HbA1c测量之间的连续血糖数据。CHbA1c使用后来的HbA1c数据进行了前瞻性验证，这些数据最初并未用于确定个人运动参数。与估计的HbA1c(EHbA1c)和血糖管理指标(GMI)相比，cHbA1c具有临床相关性的准确性提高，在实验室HbA1c的±0.5%(±5.5 mmol/mol)范围内20%或更多。CHbA1c计算的平均绝对偏差为0.11%(1.2 mm o l/m ol)，显著低于eHbA1c和GMI的0.54%(5.9 m o l/m o l)和0.47%(5.1 m o l/m ol)。我们的研究表明，与eHbA1c和GMI相比，cHbA1c在反映实验室HbA1c方面具有更好的性能，使其成为临床常规使用的可靠血糖指标。
A recent kinetic model proposed a new individualized glycaemic marker, calculated HbA1c (cHbA1c), based on kinetic parameters and glucose levels that are specific to each person. The aims of the current work were to validate the accuracy of this glucose metric for clinical use and evaluate data requirements for the estimation of personal kinetic factors. We retrieved HbA1c and glucose data from a group of 51 Japanese T1D patients under sensor-augmented pump (SAP) therapy. Two patient-specific kinetic parameters were identified by data sections, defined as continuous glucose data between two laboratory HbA1c measurements. The cHbA1c was prospectively validated employing subsequent HbA1c data that were not originally used to determine personal kinetic parameters. Compared to estimated HbA1c (eHbA1c) and glucose management indicator (GMI), cHbA1c showed clinically relevant accuracy improvement, with 20% or more within ±0.5% (±5.5 mmol/mol) of laboratory HbA1c. The mean absolute deviation of the cHbA1c calculation was 0.11% (1.2 mmol/mol), substantially less than for eHbA1c and GMI at 0.54% (5.9 mmol/mol) and 0.47% (5.1 mmol/mol), respectively. Our study shows superior performance of cHbA1c compared with eHbA1c and GMI at reflecting laboratory HbA1c, making it a credible glucose metric for routine clinical use.
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影响因子：
168.9
作者：
Turner, RC;Holman, RR;Ward, JD
通讯作者：
Ward, JD
影响因子：
39.2
作者：
Bergenstal, Richard M.;Gal, Robin L.;Beck, Roy W.
通讯作者：
Beck, Roy W.
影响因子：
5
作者：
Xu, Yongjin;Dunn, Timothy C.;Ajjan, Ramzi A.
通讯作者：
Ajjan, Ramzi A.
影响因子：
16.2
作者：
Bergenstal RM;Beck RW;Close KL;Grunberger G;Sacks DB;Kowalski A;Brown AS;Heinemann L;Aleppo G;Ryan DB;Riddlesworth TD;Cefalu WT
通讯作者：
Cefalu WT
影响因子：
158.5
作者：
SHAMOON, H;DUFFY, H;SIEBERT, C
通讯作者：
SIEBERT, C