Relationship between cathepsin-D content and disease free survival in node-negative breast cancer patients: A meta-analysis
Relationship between cathepsin-D content and disease free survival in node-negative breast cancer patients: A meta-analysis
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DOI：
10.1038/bjc.1997.442
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发表时间：
1997-01-01
影响因子：
8.8
通讯作者：
Messori, A
中科院分区：
文献类型：
--
作者：
Ferrandina, G;Scambia, G;Messori, A
一些报告已经评估了组织蛋白酶D与淋巴结阴性乳腺癌患者的总生存期或无病生存期之间的相关性。由于迄今为止报告的数据相互矛盾，因此进行了荟萃分析以澄清这一问题。我们的荟萃分析纳入了11项研究（共2690例患者）。对删失数据采用了特定的荟萃分析方法，无病生存期是主要终点。组织蛋白酶D水平低的患者的无病生存率显著高于组织蛋白酶D水平高的患者（1 - 7年的荟萃分析比值比为0.59 - 0.60）。对8项基于细胞溶质试验的研究数据进行的二次荟萃分析得出了基本相似的结果。我们研究的一个局限性是，在我们的荟萃分析中纳入的各种研究中，定义高和低组织蛋白酶D浓度的截止值并不相同（范围为20至78 pmol mg（-1）蛋白），因此在数据的统计分析中引入了可能的偏倚。然而，基于被广泛接受的所谓发表偏倚方法的模拟表明，需要100多项无效研究才能将我们的结果引导到无统计学意义的水平。考虑到我们的荟萃分析结果，我们得出结论，目前可用的数据证实了淋巴结阴性乳腺癌患者的高组织蛋白酶D值与无病生存率差之间存在统计学显著相关性。
Several reports have evaluated the correlation between cathepsin-D and overall survival or disease-free survival in node-negative breast cancer patients. Because conflicting data have so far been reported, a meta-analysis was conducted to clarify this problem. Eleven studies were included in our meta-analysis (total of 2690 patients). A specific meta-analytical methodology for censored data was used, and disease-free survival was the primary end point. Patients with tow cathepsin-D levels had a significantly better disease-free survival than patients with high cathepsin-D Values (meta-analytical odds ratio from 0.59 to 0.60 over the interval from 1 to 7 years). A secondary metaanalysis conducted exclusively on the data from eight studies based on cytosol assay gave substantially similar results. One limitation of our study is that the cut-off values to define high and low cathepsin-D concentrations were not identical in the Various studies included in our meta-analysis (range from 20 to 78 pmol mg(-1) protein), thus introducing a possible bias in the statistical analysis of the data. However, a simulation based on the well-accepted method of the so-called publication bias showed that more than 100 null studies would be required to lead our results to a statistical level of non-significance. Considering the results of our meta-analysis, we conclude that the data presently available confirm a statistically significant association between high cathepsin-D Values and poor disease-free survival in node-negative breast cancer patients.