Incidence of fatal adverse drug reactions:: a population based study
Incidence of fatal adverse drug reactions:: a population based study
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DOI：
10.1111/j.1365-2125.2007.03064.x
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发表时间：
2008-04-01
影响因子：
3.4
通讯作者：
Hagg, Staffan
中科院分区：
文献类型：
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作者：
Wester, Karin;Jonsson, Anna K.;Hagg, Staffan
AIMSTto确定致命的药物不良反应（FADRs）在瑞典population.METHODSEvery第七随机选择在瑞典东南部的三个县在2001年1月1日至2001年12月31日死亡的原因登记的发病率。相关病例记录（医院和/或初级保健中心和法医档案）进行审查，以确定可疑的药物相关死亡。在1574例死亡的研究受试者中，49例（3.1%; 95%CI 2.2%，4.0%）被怀疑死于FADR。最常见的疑似FADR为胃肠道出血（n = 18; 37%）、中枢神经系统出血（n = 14; 29%）、心血管疾病（n = 5; 10%）、其他出血（n = 4; 8%）和肾功能不全（n = 3; 6%）。FADR中最常见的药物是抗血栓药物（n = 31; 63%），其次是非甾体抗炎药（NSAID）（n = 9; 18%）、抗抑郁药（n = 7; 14%）和心血管药物（n = 4; 8%）。在所有639例住院死亡病例中，有41例（6.4%; 95%CI 4.5%，8.3%）被怀疑是由于FADRs. CONCLUSIONSSFADRs的医疗负担是显着的。在大多数FADR中观察到出血;大多数这些事件涉及抗血栓形成药物或NSAID。这些结果表明，应采取预防措施，以减少毒品造成的死亡人数。
AIMSTo determine the incidence of fatal adverse drug reactions (FADRs) in a Swedish population.METHODSEvery seventh randomly selected deceased in three counties in South-east Sweden during 1 January 2001-31 December 2001 was identified in the Cause of Death Register. Relevant case records (hospitals and/or primary care centres and medicolegal files) were reviewed to identify suspected drug-related fatalities.RESULTSOf 1574 deceased study subjects, 49 (3.1%; 95% CI 2.2%, 4.0%) were suspected to have died from FADRs. The most common suspected FADRs were gastrointestinal haemorrhages (n = 18; 37%), central nervous system haemorrhages (n = 14; 29%), cardiovascular disorders (n = 5; 10%), other haemorrhages (n = 4; 8%) and renal dysfunction (n = 3; 6%). The drugs most commonly implicated in FADRs were antithrombotic drugs (n = 31; 63%), followed by nonsteroidal anti-inflammatory drugs (NSAIDs) (n = 9; 18%), antidepressants (n = 7; 14%) and cardiovascular drugs (n = 4; 8%). Of all the 639 fatalities in hospital 41 (6.4%; 95% CI 4.5%, 8.3%) were suspected to be due to FADRs.CONCLUSIONSThe medical burden of FADRs is significant. Haemorrhages were seen in a majority of the FADRs; antithrombotic agents or NSAIDs were implicated in most of these events. These results suggest that preventive measures should be taken to reduce the number of deaths caused by drugs.