Functional differences among those high and low on a trait measure of psychopathy
Functional differences among those high and low on a trait measure of psychopathy
复制标题
DOI：
10.1016/j.biopsych.2004.06.030
复制
发表时间：
2004-10-01
影响因子：
10.6
通讯作者：
End, A
中科院分区：
文献类型：
--
作者：
Gordon, HL;Baird, AA;End, A
背景资料：已经确定的是，在精神病测量中得分高的人在执行需要解释他人情绪状态的任务时表现出困难。本研究的目的是阐明情绪和认知与非精神病患者在标准精神病人格问卷（PPI）上个体差异的关系。20名参与者完成了PPI调查完成后，对他们在情感-人际因素上的得分进行了平均分割，并将参与者分为高组或低组。当参与者执行识别任务时，收集了功能性磁共振成像数据，该任务需要关注目标刺激的影响或身份。结果。在情感识别任务中，高分和低分受试者在额叶皮层和杏仁核的几个子区域中观察到了显着差异。没有显着差异被发现在响应组之间的身份recognition conditions.Conclusions：结果表明，参与者得分高的PPI，虽然没有行为上的不同，表现出显着不同的模式的神经活动（测量血氧水平依赖的对比度）在响应任务，需要情感处理。结果表明，在非精神病人群中，一种独特的神经信号与个性差异有关。
Background: It has been established that individuals who score high on measures of psychopathy demonstrate difficulty when performing tasks requiring the interpretation of others emotional states. The aim of this study was to elucidate the relation of emotion and cognition to individual differences on a standard psychopathy personality inventory (PPI) among a nonpsychiatricMethods. Twenty participants completed the PPI Following survey completion, a mean split of their scores on the emotional-interpersonal factor was performed, and participants were placed into a high or low group. Functional magnetic resonance imaging data were collected while participants performed a recognition task that required attention be given to either the affect or identity of target stimuli.Results. No significant behavioral differences were found. In response to the affect recognition task, significant differences between high- and low-scoring subjects were observed in several subregions of the frontal cortex, as well as the amygdala. No significant differences were found between the groups in response to the identity recognition condition.Conclusions: Results indicate that participants scoring high on the PPI, although not behaviorally distinct, demonstrate a significantly different pattern of neural activity (as measured by blood oxygen level-dependent contrast) in response to tasks that require affective processing. The results suggest a unique neural signature associated with personality differences in a nonpsychiatric population.