Intestinal Schistosomiasis in Mothers and Young Children in Uganda Investigation of Field-Applicable Markers of Bowel Morbidity
Intestinal Schistosomiasis in Mothers and Young Children in Uganda Investigation of Field-Applicable Markers of Bowel Morbidity
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DOI：
10.4269/ajtmh.2010.10-0307
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发表时间：
2010-11-01
影响因子：
3.3
通讯作者：
Stothard, J. Russell
中科院分区：
文献类型：
--
作者：
Betson, Martha;Figueiredo, Jose Carlos Sousa;Stothard, J. Russell
为了在撒哈拉以南非洲国家一级控制肠道血吸虫病，需要现场适用的标记物来测量与该病相关的发病率。本研究的目的是确定粪便钙保护素或粪便潜血检测是否可作为肠道血吸虫病的发病率指标。这项研究是在乌干达进行的，一组幼儿(n=1 327)和他们的母亲(n=726)的虫卵显性血吸虫病的患病率分别为27.2%和47.6%。未发现血吸虫病感染与儿童粪钙保护素之间的关联(n=83，OR[OR]=1 08，尽管母亲粪便潜血与儿童曼氏血吸虫感染呈负相关(n=58，OR=0.17，P=0.043)，但与儿童曼氏血吸虫感染密切相关(n=814，OR=2.3，P<；和母亲(n=448，OR=1.95 P=0.004)粪便潜血似乎有助于衡量与肠道血吸虫病相关的发病率，并可用于评估控制计划对疾病的影响
To control intestinal schistosomiasis at a national level in sub-Saharan Africa, there is a need for field applicable markers to measure morbidity associated with this disease The purpose of this study was to determine whether fecal calprotectin or fecal occult blood assays could be used as morbidity indicators for intestinal schistosomiasis The study was carried out in Uganda with a cohort of young children (n = 1 327) and their mothers (n = 726) The prevalence of egg patent schistosomiasis was 27 2% in children and 47 6% in mothers No association was found between schistosomiasis infection and fecal calprotectin in children (n = 83, odds ratio [OR] = 1 08, P = 0 881) although an inverse relationship (n = 58, OR = 0 17 P = 0 043) was found in mothers Fecal occult blood was strongly associated with Schistosoma mansoni infection in children (n = 814, OR = 2 30, P < 0 0001) and mothers (n = 448, OR = 1 95 P = 0 004) Fecal occult blood appears to be useful for measuring morbidity associated with intestinal schistosomiasis and could be used in assessing the impact of control programs upon disease