Local regeneration of dentin-pulp complex using controlled release of fgf-2 and naturally derived sponge-like scaffolds.
Local regeneration of dentin-pulp complex using controlled release of fgf-2 and naturally derived sponge-like scaffolds.
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DOI：
10.1155/2012/190561
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发表时间：
2012
影响因子：
2.1
通讯作者：
Washio A
中科院分区：
文献类型：
--
作者：
Kitamura C;Nishihara T;Terashita M;Tabata Y;Washio A
最近已经开发了修复和牙髓手术，试图在暴露于外部刺激（例如龋齿感染或创伤性损伤）后保持牙髓的活力。当对牙髓的损伤是可逆的时，牙髓伤口愈合可以进行，而不可逆的损伤引起牙髓的病理变化，最终需要将其去除。非重要牙齿失去了防御能力，并严重受损，导致拔牙。牙本质牙髓复合体再生治疗的发展是重要的，以克服目前可用的治疗的局限性。已经提出了三种再生牙本质-牙髓复合体的策略：整个牙齿的再生，从切断的牙髓中再生牙本质-牙髓复合体，以及从根尖牙髓或根尖周组织再生牙髓。在本文中，我们专注于局部再生的牙本质-牙髓复合体的应用外源性生长因子和支架材料，以切断牙髓。
Restorative and endodontic procedures have been recently developed in an attempt to preserve the vitality of dental pulp after exposure to external stimuli, such as caries infection or traumatic injury. When damage to dental pulp is reversible, pulp wound healing can proceed, whereas irreversible damage induces pathological changes in dental pulp, eventually requiring its removal. Nonvital teeth lose their defensive abilities and become severely damaged, resulting in extraction. Development of regeneration therapy for the dentin-pulp complex is important to overcome limitations with presently available therapies. Three strategies to regenerate the dentin-pulp complex have been proposed; regeneration of the entire tooth, local regeneration of the dentin-pulp complex from amputated dental pulp, and regeneration of dental pulp from apical dental pulp or periapical tissues. In this paper, we focus on the local regeneration of the dentin-pulp complex by application of exogenous growth factors and scaffolds to amputated dental pulp.