Toxic metals in cord blood and later development of Type 1 diabetes.
Toxic metals in cord blood and later development of Type 1 diabetes.
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DOI：
10.15761/pd.1000186
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发表时间：
2019-06-01
期刊：
影响因子：
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通讯作者：
Guerrero-Bosagna, C
中科院分区：
文献类型：
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作者：
Ludvigsson, J;Andersson-White, P;Guerrero-Bosagna, C
由于环境或生活方式的改变，1型糖尿病(T1D)的发病率有所增加。在现代社会中，重金属的传播有所增加。由于自身免疫过程通常已经开始，我们假设胎儿时期暴露于有毒金属可能有助于儿童T1D的发展。我们分析了20名后来发展为T1D(先证者)的儿童脐带血中的砷(As)、铝(Al)、镉(Cd)、锂(Li)、汞(Hg)、铅(Pb)，并与40名年龄和性别匹配的对照组进行了比较。用硝酸消解后，用超灵敏的电感耦合等离子体扇区场质谱(ICPSFMS)对脐带血中的重金属进行分析。大多数儿童脐带血中的金属浓度没有增加。然而，后来患上T1D的儿童与非糖尿病对照组相比，脐带血中铝的浓度(P=0.006)更经常地升高(超过检测限；LOD)，也更经常地汞和砷(N.S)。我们的结论是，如果在其他出生队列试验中得到证实，怀孕期间接触有毒金属可能是导致疾病过程的几个环境因素之一。
The incidence of type 1 diabetes (T1D) has increased explained by changes in environment or lifestyle. In modern society dissemination of heavy metals has increased. As the autoimmune process usually starts already, we hypothesized that exposure to toxic metals during fetal life might contribute to development of T1D in children. We analysed arsenic (AS), aluminium (Al), cadmium (Cd), lithium (Li), mercury (Hg), lead (Pb), in cord blood of 20 children who later developed T1D (probands), and in 40 age-and sex-matched controls. Analysis of heavy metals in cord blood was performed by ALS Scandinavia AB (Lulea, Sweden) using the 'ultrasensitive inductively coupled plasma sector field mass spectrometry method' (ICP-SFMS) after acid digestion with HNO3. Most children had no increased concentrations of the metals in cord blood. However, children who later developed T1D had more often increased concentrations (above limit of detection; LOD) of aluminium (p = 0.006) in cord blood than the non-diabetic controls, and also more often mercury and arsenic (n.s). Our conclusion is that exposure to toxic metals during pregnancy might be one among several contributing environmental factors to the disease process if confirmed in other birth cohort trials.