Stereotactic radiosurgery: principles and comparison of treatment methods.
Stereotactic radiosurgery: principles and comparison of treatment methods.
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立体定向放射外科：治疗方法的原理和比较。
DOI：
10.1227/00006123-199302000-00014
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发表时间：
1993
期刊：
影响因子：
4.8
通讯作者：
M. Apuzzo
中科院分区：
文献类型：
--
作者：
G. Luxton;Z. Petrovich;G. Jozsef;L. Nedzi;M. Apuzzo
立体定向放射外科的方法进行审查和比较方面的技术因素和发表的临床结果。重离子束，Leksell钴-60伽玛刀，和传统的直线加速器（直线加速器）进行了比较，剂量学，放射生物学，治疗计划，成本，人员需求，和易用性。对动静脉畸形治疗效果的临床结果列表，并描述了放射外科的其他应用。得出的结论是，虽然有剂量学和放射生物学的优势，带电粒子束，最终可能证明在放射外科应用于大（> 30 mm）病变的关键，这些优势尚未证明临床效果。在另一方面，同样出色的临床结果获得了小病变与光子束-伽玛刀和直线加速器。对于小的球形目标，伽马射线和X射线束剂量分布之间只有微小的差异。与直线加速器相比，伽玛刀的机械精度是上级的。上级机械精度对于大多数临床目标的重要性有限，因为基于放射成像的颅目标定位的不准确性大于+/- 1 mm的典型直线加速器不准确性。直线加速器的治疗计划未标准化，但现有系统基于众所周知的算法。直线加速器允许灵活的、随时访问个性化的束流控制，而没有固有的场尺寸限制。因此，与使用伽马单元实现的剂量分布相比，对于一个或多个尺寸大于25 mm的非球形靶，更容易实现均匀的剂量分布。（250字处删节）
Methods of stereotactic radiosurgery are reviewed and compared with respect to technical factors and published clinical results. Heavy-ion beams, the Leksell cobalt-60 gamma knife, and the conventional linear accelerator (linac) are compared with respect to dosimetry, radiobiology, treatment planning, cost, staffing requirements, and ease of use. Clinical results on the efficacy of treatment of arteriovenous malformations are tabulated, and other applications of radiosurgery are described. It is concluded that although there are dosimetric and radiobiological advantages to charged-particle beams that may ultimately prove critical in the application of radiosurgery to large (> 30 mm) lesions, these advantages have not yet demonstrated clinical effect. On the other hand, equally excellent clinical results are obtained for small lesions with photon beams--the gamma knife and the linac. There are only minor differences between gamma and x-ray beam dose distributions for small, spherical-shaped targets. Mechanical precision is superior for the gamma knife as compared with the linac. The superior mechanical precision is of limited importance for most clinical targets, because inaccuracy of cranial target localization based on radiological imaging is greater than the typical linac imprecision of +/- 1 mm. Treatment planning for the linac is not standardized, but existing systems are based on well-known algorithms. The linac allows flexible, ready access to individualized beam control, without intrinsic field size limitations. Thus, it is more readily possible to achieve homogeneous dose distributions for nonspherical targets with one or more dimensions greater than 25 mm, as compared with that achieved with the gamma unit.(ABSTRACT TRUNCATED AT 250 WORDS)
用于放射治疗和立体定向放射外科的加速氦离子束。
影响因子：
3.8
作者：
Ludewigt,BA;Chu,WT;Phillips,MH;Renner,TR
通讯作者：
Renner,TR
动态场整形以优化立体定向放射外科手术。
DOI：
10.1016/0360-3016(91)90283-a
发表时间：
1991
期刊：
International journal of radiation oncology, biology, physics
影响因子：
--
作者：
Leavitt,DD;GibbsJr,FA;Heilbrun,MP;Moeller,JH;TakachJr,GA
通讯作者：
TakachJr,GA
三维体积可视化包应用于立体定向放射外科治疗计划。
DOI：
10.1016/0360-3016(91)90801-a
发表时间：
1991
期刊：
International journal of radiation oncology, biology, physics
影响因子：
--
作者：
Gehring,MA;Mackie,TR;Kubsad,SS;Paliwal,BR;Mehta,MP;Kinsella,TJ
通讯作者：
Kinsella,TJ