SLANTED LATTICE-SHAPED MICROCHANNEL NETWORKS FOR CONTINUOUS SORTING OF MICROPARTICLES AND CELLS
SLANTED LATTICE-SHAPED MICROCHANNEL NETWORKS FOR CONTINUOUS SORTING OF MICROPARTICLES AND CELLS
复制标题
用于连续分选微粒和细胞的倾斜格子状微通道网络
DOI：
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发表时间：
2013
期刊：
影响因子：
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通讯作者：
M. Seki
中科院分区：
文献类型：
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作者：
Wataru Seko;M. Yamada;M. Seki
在这里，我们提出了一种采用倾斜格子状微通道网络的连续粒子/细胞分选系统。右向和左向流道密度的差异在每个交叉口产生了不对称的流量分布，导致大颗粒从流线上分离出来。我们成功地基于粒度对微粒进行了高精度的分选，并清楚地表明微通道密度和倾斜角度共同控制了分离效率。此外，作为细胞分选的应用，血细胞从稀释的血液样本中分离出来。提出的颗粒/细胞分选方案将成为微流控化学/生物实验装置中一种简单而通用的单元操作。
Here we present a continuous particle/cell sorting system employing a slanted lattice-shaped microchannel networks. The difference in the densities of the rightand left-directing channels generates the asymmetric flow distribution at each intersection, resulting in the separation of large particles from the streamline. We successfully sorted microparticles based on size with a high accuracy, and clearly showed that both the microchannel densities and the slanted angles dominated the separation efficiencies. In addition, as an application for cell sorting, blood cells were separated from a diluted blood sample. The presented scheme of particle/cell sorting would become a simple but versatile unit operation in the microfluidic apparatus for chemical/biological experiments.