Biology of Naegleria spp.
Biology of Naegleria spp.
复制标题
耐格里氏耐格里虫属的生物学
DOI：
10.1128/mr.52.1.114-133.1988
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发表时间：
1988
期刊：
影响因子：
--
通讯作者：
Marciano-Cabral,F
中科院分区：
文献类型：
--
作者：
Marciano-Cabral,F
The genus Naegleria consists of free-living amoebae widely distributed in soil and freshwater habitats throughout the world. These organisms characteristically undergo trans-formation from amoebae to flagellates. There are six species of Naegleria: N. fowtleri, N. aiustr (aliensis, N. lov, aniensis, N. griberi, N. jadini, and N. tliorntoni. Each species may be distinguished on the basis of cyst morphology (163, 164, 199-201, 203), temperature tolerance (91), immunologic criteria (221, 234, 235), pathogenicity (17-19), and isoenzyme patterns (51, 53, 55, 94, 111, 155, 167-169). N. gruberi, a nonpathogenic species, was the first member of the genus to be described and has been used extensively to define the molecular biology of cellular differentiation (83). Another species, N. ftmWleri, sometimes called N. aerobia (133, 199, 201) or N. invades (27), is the causative agent of primary amoebic meningoencephalitis (PAME), a rapidly fatal dis-ease of the central nervous system (CNS)(17-19). N. australiensis, originally isolated from flood waters in Aus-tralia, like N. f) it'leri, is pathogenic for mice, but the two species are antigenically and biochemically distinct (52). The pathogenicity of the two species for mice also differs: N. alustraliensis causes a subacute infection with focal menin-goencephalitis, with fewer amoebae being present in the infected CNS tissue when compared with N. fouleri infection (54). Highly pathogenic strains of N. aiustr (aliensis have been reported in Europe. The subspecies epithet N. austra-liensis subsp. italica has been proposed for these highly pathogenic strains (56). N. lovaniensis, a thermophilic envi-ronmental isolate, exhibits antigenic relatedness to N. ftw'v-leni but is not pathogenic for mice (205). N. jadini, isolated from swimming-pool water, is antigenically distinct from other species of Naegleria and is not pathogenic for mice (236). N. thlorntoni was classified as Didascalus thorntoni by Singh (199) based on the pattern of nuclear division and the absence of an interzonal body. Page (163, 164) placed this species in the genus Naegleria. Human disease caused by free-living amoebae was first reported in 1965 by Fowler and Carter, who studied four patients with PAME in South Australia (79). Subsequently, accounts of patients with PAME from the United States were reported by Butt in Florida (12, 13) and by Patras and Andujar in Texas (165). A retrospective study conducted by dos Santos (66) indicated that an epidemic of PAME had occurred in Richmond, Va., from1951 to 1952. At the present time, episodes of PAME in humans have been reported from almost every continent (148, 233). The term primary amoebic meningoencephalitis" was used first by Butt (12). and later by Carter (17), to distinguish infection of
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淡水鱼中自由生活的阿米巴的分离和实验感染。
影响因子：
1.3
作者：
P. Taylor
通讯作者：
P. Taylor
可溶性杀阿米巴因子通过活化的巨噬细胞介导福氏耐格里阿米巴的细胞溶解。
影响因子：
4.3
作者：
S. Cleary;F. Marciano
通讯作者：
F. Marciano
二氧化碳：格鲁氏核菌排空的信号
DOI：
--
发表时间：
--
期刊：
影响因子：
--
作者：
Rodney F. Carter
通讯作者：
Rodney F. Carter
活化的巨噬细胞表现出直接细胞毒性、抗体依赖性细胞毒性以及福氏耐格里阿米巴变形虫的结合增强。
影响因子：
4.3
作者：
S. Cleary;F. Marciano
通讯作者：
F. Marciano
通过间接荧光抗体测试（IFAT）评估几种蜥蜴变形虫分离株之间的抗原关系。
影响因子：
1.6
作者：
L. Cerva;J. Kramar
通讯作者：
J. Kramar