Contactless Manipulation of Mixed Phase Fluids in Liquid Crystal Polymer Microtubes Assisted with Light-Driven Vortex
Contactless Manipulation of Mixed Phase Fluids in Liquid Crystal Polymer Microtubes Assisted with Light-Driven Vortex
复制标题
光驱动涡流辅助液晶聚合物微管中混合相流体的非接触操控
DOI：
10.1038/s41427-022-00424-1
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发表时间：
2022-09
影响因子：
9.7
通讯作者：
Yanlei Yu
中科院分区：
文献类型：
--
作者：
Yao Lu;Lang Qin;Quan Liu;Zichuan Li;Weijia Zhang;Chongyu Zhu;Yanlei Yu
摘要通过各向异性形状变化控制液体运动的智能通道是构建用于生化分析的微流体的一个有前途的候选通道。然而，现有的系统未能为固体交换介质与多个液相相互作用提供平台，而这是有效提取、富集和精确检测生物标志物的通用技术。本文首次报道了一种基于柔性支撑层、光变形液晶聚合物和亲水阻隔层组成的三层微管的混合相流体光/磁联合控制策略，该策略集悬浮、沉积甚至分离等非接触操作于一体。液晶聚合物的不对称光变形在微管中产生内部涡旋，使固体交换介质均匀分散到各种含水移动液滴中，从而实现目标生物标志物的高效纯化和富集。采用光/磁联合控制策略，自制便携式蛋白质分析仪具有检测时间短（20 min）、痕量样品消耗（5 μL）、检出限低（1 μ mL−1）等优点。
AbstractSmart channels that manipulate liquid motion by anisotropic shape changes represent a promising candidate to construct microfluidics for biochemical analysis. However, the existing systems fail to provide a platform for solid exchange mediums to interact with multiple liquid phases, which is a universal technique to effectively extract, enrich, and precisely detect biomarkers. Herein, a combined photo/magnetic control strategy of mixed phase fluids, which integrates the contactless operations of suspending, depositing, and even separating, is reported for the first time based on a trilayer microtube consisting of a flexible supporting layer, photodeformable liquid crystal polymer, and hydrophilic blocking layer. The asymmetric photodeformation of the liquid crystal polymer generates an internal vortex in the microtube to homogenously disperse solid exchange mediums into various aqueous moving droplets and to enable efficient purification and enrichment of the target biomarkers. A newly constructed homemade portable protein analyzer guided by the combined photo/magnetic control strategy features the advantages of a short detection time (20 min), trace sample consumption (5 μL), and a low detection limit (1 μg mL−1).
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