LEFT-VENTRICULAR INTERACTION WITH ARTERIAL LOAD STUDIED IN ISOLATED CANINE VENTRICLE
LEFT-VENTRICULAR INTERACTION WITH ARTERIAL LOAD STUDIED IN ISOLATED CANINE VENTRICLE
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DOI：
10.1152/ajpheart.1983.245.5.h773
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发表时间：
1983-01-01
影响因子：
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通讯作者：
SAGAWA, K
中科院分区：
文献类型：
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作者：
SUNAGAWA, K;MAUGHAN, WL;SAGAWA, K
建立了一个分析框架来预测由于脑室与其动脉系统之间复杂的机械相互作用而产生的每搏量(SV)。在这里，左心室和动脉系统都以它们的收缩末压(Ps)-SV关系为特征，并从这两条关系线的交点预测SV。分析的最终输出是一个公式，该公式给出了给定预负荷的SV作为心脏属性(EES、Vo和射血时间)和动脉阻抗属性(根据三元Windkesel建模)的函数。为了测试该框架用于分析脑室-动脉相互作用的有效性，首先确定了在一组特定的对照动脉阻抗条件下的心室特性。根据得到的心室特性，用解析公式预测了在非控制动脉阻抗条件和4种预负荷的不同组合下的SV。在8个离体犬的脑室中，将预测的SV与实际施加相同的动脉阻抗条件和预负荷时的实测值进行比较。所有脑室的预测SV与实测值高度相关(P<；0.0001)。平均相关系数为0.985.+-。0.004(东南)，坡度1.00。+-。0.04，y轴截距1.0+-。0.2毫升，表明预测的准确性。显然，通过Ps-SV关系表示脑室和动脉系统有助于理解这两个系统在耦合和相互作用时如何确定SV。
A framework of analysis to predict the stroke volume (SV) resulting from the complex mechanical interaction between the ventricle and its arterial system was developed. Here, both the left ventricle and the arterial system were characterized by their end systolic pressure (Ps)-SV relationships and predicted SV from the intersection of the 2 relationship lines. The final output of the analysis was a formula that gives the SV for a given preload as a function of the ventricular properties (Ees, Vo, and ejection time) and the arterial impedance properties (modeled in terms of a 3-element Windkessel). To test the validity of this framework for analyzing the ventriculoarterial interaction, the ventricular properties under a specific set of control arterial impedance conditions were 1st determined. With the ventricular properties thus obtained, the analytical formula was used to predict SV under various combinations of noncontrol arterial impedance conditions and 4 preloads. The predicted SV were compared with those measured while actually imposing the identical set of arterial impedance conditions and preload in 8 isolated canine ventricles. The predicted SV was highly correlated (P < 0.0001) with the measured 1 in all ventricles. The average correlation coefficient was 0.985 .+-. 0.004 (SE), the slope 1.00 .+-. 0.04, and the y-axis intercept 1.0 .+-. 0.2 ml, indicating the accuracy of the prediction. Apparently, the representations of ventricle and arterial system by their Ps-SV relationships are useful in understanding how these 2 systems determine SV when they are coupled and interact.