Atrial natriuretic factor: reduced cardiac content in spontaneously hypertensive rats.
Atrial natriuretic factor: reduced cardiac content in spontaneously hypertensive rats.
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心房钠尿因子：减少自发性高血压大鼠的心脏含量。
DOI：
10.1161/01.hyp.5.5.672
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发表时间：
1983
期刊：
影响因子：
8.3
通讯作者：
A. Veress
中科院分区：
文献类型：
--
作者：
H. Sonnenberg;S. Milojevic;C. Chong;A. Veress
我们最近在心脏心房组织中发现了一种有效的利钠因子。本实验旨在确定高血压是否与心钠素组织含量的改变有关。使用Okamoto品系自发性高血压大鼠及其Wistar-Kyoto对照大鼠的新鲜心房制备浸提液。使用两组麻醉的正常血容量大鼠（Sprague-Dawley）测量每种类型提取物的肾利钠和利尿氯作用。结果表明，高血压大鼠心房利钠因子含量低于对照组动物。我们推测，该因子的慢性释放可能耗尽了心房储备，并且心钠素血液水平的增加可能参与了该模型中高血压的产生和维持。
We recently discovered a potent natriuretic factor in cardiac atrial tissue. The present experiments were designed to determine whether hypertension was associated with altered tissue content of this atrial natriuretic factor. Extracts were prepared using fresh atria from spontaneously hypertensive rats of the Okamoto strain and from their Wistar-Kyoto controls. Two groups of anesthetized, normovolemic rats (Sprague-Dawley) were used to measure the renal natriuretic and chloriuretic effect of each type of extract. Results indicate that atrial content of natriuretic factor is reduced in hypertensive rats compared to control animals. We speculate that chronic release of the factor could have depleted atrial stores, and that increased blood levels of atrial natriuretic factor may be involved in the generation and maintenance of hypertension in this model.