Human papillomavirus type 6a DNA in the lung carcinoma of a patient with recurrent laryngeal papillomatosis is characterized by a partial duplication.
Human papillomavirus type 6a DNA in the lung carcinoma of a patient with recurrent laryngeal papillomatosis is characterized by a partial duplication.
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复发性喉乳头状瘤病患者肺癌中的人乳头瘤病毒 6a 型 DNA 具有部分重复的特征。
DOI：
10.1099/0022-1317-73-2-423
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发表时间：
1992
期刊：
影响因子：
--
通讯作者：
Steinberg,BM
中科院分区：
文献类型：
--
作者：
DiLorenzo,TP;Tamsen,A;Abramson,AL;Steinberg,BM
在患有复发性喉乳头状瘤病的患者的肺癌中检测到具有转录活性的人乳头瘤病毒 6a 型 (HPV-6a) DNA。该癌含有附加型 HPV-6a 基因组，该基因组具有上游调节区、晚期区域和部分早期区域的重复。在同一患者的良性喉乳头状瘤中发现的 HPV-6a 基因组不包含这种重复。提出了突变分子在恶性肿瘤发病机制中的作用。
Transcriptionally active human papillomavirus type 6a (HPV-6a) DNA was detected in a lung carcinoma of a patient with recurrent laryngeal papillomatosis. The carcinoma contained episomal HPV-6a genomes that had a duplication of the upstream regulatory region, the late region and a portion of the early region. HPV-6a genomes found in benign laryngeal papillomas from the same patient did not contain this duplication. A role for the mutant molecules in the pathogenesis of the malignancy is suggested.