Swimming training alleviated insulin resistance through Wnt3a/β-catenin signaling in type 2 diabetic rats.
Swimming training alleviated insulin resistance through Wnt3a/β-catenin signaling in type 2 diabetic rats.
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DOI：
10.22038/ijbms.2017.9473
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发表时间：
2017-11
影响因子：
2.2
通讯作者：
Lu Q
中科院分区：
文献类型：
--
作者：
Yang Q;Wang WW;Ma P;Ma ZX;Hao M;Adelusi TI;Lei-Du;Yin XX;Lu Q
越来越多的证据表明，规律的体育锻炼可以改善2型糖尿病（T2 DM）。然而，游泳对2型糖尿病胰岛素抵抗和血脂紊乱的潜在有益作用及其潜在机制尚不清楚。采用高脂饲料和低剂量链脲佐菌素（STZ）诱导大鼠2型糖尿病模型，然后进行游泳运动或不进行游泳运动。为期8周的游泳计划（每天30，60或120分钟，每周5天）降低体重，空腹血糖和空腹胰岛素。游泳可改善糖尿病大鼠的血脂紊乱，改善肌肉萎缩，并减少骨骼肌中的糖原存款。此外，游泳还抑制了糖尿病大鼠Wnt 3a/β-catenin信号通路的激活，降低了Wnt 3a mRNA和蛋白水平，上调了GSK 3 β磷酸化活性，降低了β-catenin磷酸化表达。结果提示，游泳运动通过调节Wnt 3a/β-catenin通路，有效改善T2 DM患者的胰岛素抵抗，为糖尿病及其相关疾病的治疗提供了一种新的途径。
Increasing evidence suggests that regular physical exercise improves type 2 diabetes mellitus (T2DM). However, the potential beneficial effects of swimming on insulin resistance and lipid disorder in T2DM, and its underlying mechanisms remain unclear. Rats were fed with high fat diet and given a low dosage of Streptozotocin (STZ) to induce T2DM model, and subsequently treated with or without swimming exercise. An 8-week swimming program (30, 60 or 120 min per day, 5 days per week) decreased body weight, fasting blood glucose and fasting insulin. Swimming ameliorated lipid disorder, improved muscular atrophy and revealed a reduced glycogen deposit in skeletal muscles of diabetic rats. Furthermore, swimming also inhibited the activation of Wnt3a/β-catenin signaling pathway, decreased Wnt3a mRNA and protein level, upregulated GSK3β phosphorylation activity and reduced the expression of β-catenin phosphorylation in diabetic rats. The trend of the result suggests that swimming exercise proved to be a potent ameliorator of insulin resistancein T2DM through the modulation of Wnt3a/β-catenin pathway and therefore, could present a promising therapeutic measure towards the treatment of diabetes and its relatives.