SEX DIFFERENCES IN TASTE PREFERENCE FOR A SALT SOLUTION IN RAT
SEX DIFFERENCES IN TASTE PREFERENCE FOR A SALT SOLUTION IN RAT
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DOI：
10.1016/0031-9384(72)90358-7
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发表时间：
1972-01-01
影响因子：
2.9
通讯作者：
NOVAKOVA, V
中科院分区：
文献类型：
--
作者：
KRECEK, J;STIBRAL, K;NOVAKOVA, V
采用两瓶自由选择法研究了30日龄至成年期雌雄大鼠对水和3% NaCl溶液的摄取量。在性成熟期之前没有观察到性别差异。从那时起，女性比男性喝更多的盐溶液；总液体中NaCl浓度的性别差异也很明显。这些性别差异也存在于10天大时进行性腺切除的成年大鼠中。自由选择实验完成后，研究成年雄鼠和发情雌鼠下丘脑和海马细胞总RNA含量。在女性中，没有观察到增加盐摄入量的影响。在男性中，盐摄入量的增加与所有细胞中RNA含量的增加有关。讨论了下丘脑在盐摄入性别分化中的作用。
A two-bottle free choice method was employed to investigate the water and 3% NaCl solution intake in rats of both sexes from the age of 30 days to adulthood. No sex difference was observed until the period of sexual maturation was reached. From that time on females drank more of the salt solution than males; the sex difference was apparent also in the NaCl concentration in total fluids consumed. These sexual differences existed also in adult rats which had been gonadectomised at the age of 10 days. After the free choice experiment was completed, the total RNA content in cells of hypothalamus and hippocampus of adult males and diestrous females was investigated. In females no effect of increased salt intake was seen. In males increased salt intake was associated with increased RNA content in all cells investigated. The role of the hypothalamus in sexual differentiation of salt intake is discussed.