THE EFFECTS OF TIANEPTINE AND OTHER ANTIDEPRESSANTS ON A RAT MODEL OF DEPRESSION
THE EFFECTS OF TIANEPTINE AND OTHER ANTIDEPRESSANTS ON A RAT MODEL OF DEPRESSION
复制标题
DOI：
10.1192/s0007125000296682
复制
发表时间：
1992-02-01
影响因子：
10.5
通讯作者：
WHITTON, PS
中科院分区：
文献类型：
--
作者：
CURZON, G;KENNETT, GA;WHITTON, PS
根据束缚大鼠两小时后的测量结果，建立了一种抑郁模型。该模型与皮质酮升高有关，反映了女性抑郁症的较高发生率，并显示了突触后5-羟色胺功能的增强和适应。研究了替尼普汀和其他抗抑郁药物对模型的影响。使用地塞帕明、舍曲林(胺摄取抑制剂)和氯氮卓酮进行慢性预治疗，可使束缚后的野外活动恢复正常。单独大剂量的8-OH-DPAT、吉培酮(5-羟色胺激动剂)和替尼普汀在束缚后可使开阔活动恢复正常，而地昔帕明、氯氮卓酮和安定则不能。值得注意的是，替尼普汀降低了受体对5-羟色胺的利用率。
A model of depression based on measurements made after restraining rats for two hours has been developed. The model is associated with elevation in corticosterone, reflects the higher incidence of depression in women, and shows increased post-synaptic 5-HT function with adaptation. The effects of tianeptine and other antidepressants on the model were studied. Chronic pre-treatment with desipramine, sertraline (amine uptake inhibitors), and chlordiazepoxide normalised open field activity after restraint. Single high doses, post-restraint, of 8-OH-DPAT, gepirone (5-HT agonists), and tianeptine normalised open field activity, whereas desipramine, chlordiazepoxide, and diazepam did not. It is of considerable interest that tianeptine decreased the availability of 5-HT to receptors.