A new blue light-emitting phototherapy device: a prospective randomized controlled study.
A new blue light-emitting phototherapy device: a prospective randomized controlled study.
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DOI：
10.1016/s0022-3476(00)75202-4
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发表时间：
2000-06
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通讯作者：
D. Seidman;D. Seidman;D. Seidman;J. Moise;J. Moise;J. Moise;Z. Ergaz;Z. Ergaz;Z. Ergaz;A. Laor;A. Laor;A. Laor;H. Vreman;H. Vreman;H. Vreman;D. Stevenson;D. Stevenson;D. Stevenson;R. Gale;R. Gale;R. Gale
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作者：
D. Seidman;D. Seidman;D. Seidman;J. Moise;J. Moise;J. Moise;Z. Ergaz;Z. Ergaz;Z. Ergaz;A. Laor;A. Laor;A. Laor;H. Vreman;H. Vreman;H. Vreman;D. Stevenson;D. Stevenson;D. Stevenson;R. Gale;R. Gale;R. Gale
目的评价一种新型窄蓝光光疗光源的疗效。该装置由高强度氮化镓发光二极管（led）制成，在相似的光强度下与传统光疗进行了比较。在耶路撒冷设立两所大学附属社区医院。前瞻性开放随机研究。参与者69名患有黄疸但其他方面健康的足月婴儿，符合美国儿科学会实践参数设定的光疗入门标准。主要观察指标：光疗持续时间和血清总胆红素（TSB）浓度下降速率。结果接受LED治疗的新生儿与接受常规光疗的新生儿在治疗开始和结束时的平均TSB浓度没有差异。两组患者光疗时间及TSB浓度降低率差异无统计学意义。经混合因素线性回归分析调整后，接受LED光疗法的新生儿TSB平均下降率为- 3.16 μmol/L/h(95%置信限为- 4.81,- 1.51)，而接受常规光疗法的新生儿TSB平均下降率为- 2.19 μmol/L/h (- 3.99, - 0.40) （P < .14）。所有新生儿均未发现任何副作用。结论蓝色氮化镓LED装置与常规光疗效果相当，易于护理人员接受。未来的LED光疗设备可以提供更高的辐照度，因此更有效，并提供一种新的高度通用的方法来治疗黄疸。
ObjectiveTo evaluate the efficacy of a new phototherapy light source with a narrow luminous blue spectrum. The device, made with high-intensity gallium nitride light-emitting diodes (LEDs), was compared with conventional phototherapy at similar light intensities.SettingTwo university-affiliated community hospitals in Jerusalem.DesignProspective open randomized study.ParticipantsSixty-nine jaundiced, but otherwise healthy, term infants who met the entry criteria for phototherapy set by the American Academy of Pediatrics' Practice Parameter.Main outcome measuresThe duration of phototherapy and the rate of decrease in total serum bilirubin (TSB) concentration.ResultsThe mean TSB concentrations at initiation and termination of treatment did not differ between newborns receiving LED and those receiving conventional phototherapy. The duration of phototherapy and the rate of decrease in TSB concentration were not statistically different in the 2 groups. The average rate of decrease in TSB after adjustment by a linear regression analysis for confounding factors was −3.16 μmol/L/h (95% confidence limits −4.81, −1.51) in newborns receiving LED phototherapy compared with −2.19 μmol/L/h (−3.99, −0.40) in those treated with conventional phototherapy (P < .14). No side effects were noted in any of the newborns.ConclusionsThe blue gallium nitride LED device is as effective as conventional phototherapy and is readily accepted by nursing staff. Future LED phototherapy devices can provide much higher irradiance, and thus greater efficacy, and offer a new highly versatile approach to the treatment of jaundice.