Vagal and hormonal influences on gastric secretion in duodenal ulcer disease
Vagal and hormonal influences on gastric secretion in duodenal ulcer disease
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迷走神经和激素对十二指肠溃疡病胃分泌的影响
DOI：
10.1007/bf01469003
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发表时间：
1976
期刊：
影响因子：
--
通讯作者：
S. Konturek
中科院分区：
文献类型：
--
作者：
S. Konturek
本文介绍了十二指肠溃疡病中胃分泌过多的病理生理学概念，并讨论了迷走神经和胃肠激素特别是胃泌素的作用。十二指肠溃疡患者在胃酸、胃蛋白酶分泌和胃泌素释放方面形成异质组。他们与健康受试者的不同之处可能在于几个壁定义的缺陷，包括壁细胞和消化细胞质量增加、分泌酸和胃蛋白酶的能力增加、对壁细胞的迷走神经驱动增加、胃窦高反应性、胃窦和十二指肠自动调节机制的有效性降低、分泌素释放缺陷、胃排空增加以及十二指肠胃酸负荷清除缺陷。很少有人知道有多少比例的十二指肠溃疡患者患有各种病理紊乱，这些变化的机制是什么。
Current concepts on the pathophysiology of gastric hypersecretion in duodenal ulcer disease have been presented and the role of vagal nerves and gastrointestinal hormones particularly gastrin has been discussed. Duodenal ulcer patients form a heterogenous group with regard to the gastric acid and pepsin secretion and gastrin release. They may differ from healthy subjects by several wall defined defects including an increased mass of parietal and peptic cells, increased capacity to secrete acid and pepsin, increased vagal drive to the parietal cells, hyperreactivity of antrum, decreased effectiveness of antral and duodenal autoregulatory mechanisms, defective release of secretin, increased gastric emptying and defective removal of gastric acid load from the duodenum. Very little is known what proportion of duodenal ulcer patients suffer from various pathologic disturbences and what are the mechanisms underlying these changes.