Current progress in xenogeneic tolerance.
Current progress in xenogeneic tolerance.
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DOI：
10.1097/mot.0b013e32835090f6
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发表时间：
2012-04
影响因子：
2.2
通讯作者：
Scalea J
中科院分区：
文献类型：
--
作者：
Yamada K;Scalea J
本文对异种移植后受体免疫反应的研究现状进行了综述。此外，我们还介绍了诱导异种耐受性诱导的最新进展。人们对异种器官移植仍有很大的兴趣。最近，对大型和小型动物模型中T细胞异种耐受性机制的描述已经改善了异种移植物的存活率。此外，包括CD39、CD44和CD47在内的细胞信号机制也被证明是非常重要的。使用混合嵌合方法在异种模型中的耐受性可能是令人鼓舞的，特别是考虑到最近巨噬细胞诱导异种供体细胞吞噬作用的澄清。诱导对异种抗原的耐受性仅在小动物中完成，然而移植物在大型动物模型中的存活率继续提高。为了继续取得成功，需要进一步澄清对异种抗原的适应性和先天免疫反应。
The present review updates the current status of research regarding the immunologic responses of the recipient following xenotransplantation. Additionally, we present the recent progress with attempts to induce xenogeneic tolerance induction. There continues to be great interest in xenotransplantation. Recently, descriptions of the mechanisms responsible for attempted T cell xenogeneic tolerance in both large and small animal models have improved xenogeneic graft survivals. Additionally, the cellular signaling mechanisms, such as those involving CD39, CD44, and CD47 are proving to be highly important. Using the mixed chimerism approach to tolerance in xenogeneic model may be encouraging, especially given the recent clarification of the role for macrophage induced phagocytosis of xenogeneic donor cells. Induction of tolerance to xenogeneic antigens has been accomplished only in small animals, however graft survivals in large animal models continue to improve. Further clarification of both the adaptive and innate immune responses to xenogeneic antigens are required for success to continue.